Products Categories
CAS No.: | 53617-36-0 |
---|---|
Name: | 1-METHYL-4-(PIPERIDIN-4-YL)-PIPERAZINE |
Article Data: | 6 |
Molecular Structure: | |
Formula: | C10H21N3 |
Molecular Weight: | 183.297 |
Synonyms: | 1-Methyl-4-(4-piperidinyl)piperazine;1-Methyl-4-(piperidin-4-yl)piperazine;(1-methyl-4-piperidin-4-yl)-piperazine; |
Density: | 0.992g/cm3 |
Melting Point: | 53-56oC |
Boiling Point: | 260.9oC at 760 mmHg |
Flash Point: | 113.8oC |
Solubility: | Soluble in water. |
Hazard Symbols: | Xi |
PSA: | 18.51000 |
LogP: | 0.19040 |
1-methyl-4-(piperidin-4-yl)piperazine
Conditions | Yield |
---|---|
100% | |
With palladium on activated charcoal; hydrogen In methanol at 20℃; under 3750.38 Torr; for 2h; | 74.9% |
1-methyl-piperazine
N-tert-butyloxycarbonylpiperidin-4-one
1-methyl-4-(piperidin-4-yl)piperazine
Conditions | Yield |
---|---|
With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 0 - 20℃; for 16h; | 60% |
Stage #1: 1-methyl-piperazine; N-tert-butyloxycarbonylpiperidin-4-one With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 0 - 20℃; for 16h; Stage #2: With hydrogenchloride In methanol at 40℃; for 12h; | 60% |
Multi-step reaction with 2 steps 1: acetic acid; sodium tris(acetoxy)borohydride / ethanol / 12 h / 20 °C 2: hydrogenchloride / methanol / 12 h / 0 °C View Scheme |
N-tert-butyloxycarbonylpiperidin-4-one
1-methyl-4-(piperidin-4-yl)piperazine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 0 - 20 °C 2: hydrogenchloride / methanol / 12 h / 40 °C View Scheme |
1-methyl-4-(piperidin-4-yl)piperazine
Conditions | Yield |
---|---|
With hydrogenchloride In methanol at 40℃; for 12h; | 0.826 g |
With hydrogenchloride In methanol at 0℃; for 12h; |
1-methyl-piperazine
1-methyl-4-(piperidin-4-yl)piperazine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 0 - 20 °C 2: hydrogenchloride / methanol / 12 h / 40 °C View Scheme | |
Multi-step reaction with 2 steps 1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 3 h / 20 °C 2: palladium on activated charcoal; hydrogen / methanol / 2 h / 20 °C / 3750.38 Torr View Scheme |
1-phenylmethyl-4-piperidone
1-methyl-4-(piperidin-4-yl)piperazine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 3 h / 20 °C 2: palladium on activated charcoal; hydrogen / methanol / 2 h / 20 °C / 3750.38 Torr View Scheme |
4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidine-1-carboxylic acid (R)-1-carboxy-2-[3,5-dibromo-4-hydroxy-phenyl]-ethyl ester
1-methyl-4-(piperidin-4-yl)piperazine
Conditions | Yield |
---|---|
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; | 99% |
3-methoxy-4-nitrobenzoic acid
1-methyl-4-(piperidin-4-yl)piperazine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; | 98% |
1-methyl-4-(piperidin-4-yl)piperazine
4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidine-1-carboxylic acid (R)-1-(4-amino-3-methyl-5-nitro-benzyl)-2-[4-(4-methyl-piperazin-1-yl)piperidin-1-yl]-2-oxo-ethyl ester
Conditions | Yield |
---|---|
Stage #1: 4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidine-1-carboxylic acid (R)-2-(4-amino-3-methyl-5-nitro-phenyl)-1-carboxy-ethyl ester With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; DMF (N,N-dimethyl-formamide) at 20℃; for 1h; Stage #2: 1-methyl-4-(piperidin-4-yl)piperazine In tetrahydrofuran; DMF (N,N-dimethyl-formamide) at 20℃; for 4h; Stage #3: With sodium hydrogencarbonate In tetrahydrofuran; DMF (N,N-dimethyl-formamide); water | 97% |
Stage #1: 4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidine-1-carboxylic acid (R)-2-(4-amino-3-methyl-5-nitro-phenyl)-1-carboxy-ethyl ester With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; DMF (N,N-dimethyl-formamide) at 20℃; for 1h; Stage #2: 1-methyl-4-(piperidin-4-yl)piperazine In tetrahydrofuran; DMF (N,N-dimethyl-formamide) at 20℃; for 4h; | 97% |
(R)-2-tert-butoxycarbonylamino-3-(3,4-diethyl-phenyl)-propionic acid
1-methyl-4-(piperidin-4-yl)piperazine
{(R)-1-(3,4-diethyl-benzyl)-2-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butylester
Conditions | Yield |
---|---|
With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; | 97% |