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CAS No.: | 15356-70-4 |
---|---|
Name: | MENTHOL |
Article Data: | 101 |
Molecular Structure: | |
Formula: | C10H20O |
Molecular Weight: | 156.268 |
Synonyms: | CCRIS 4666;UNII-YS08XHA860; |
EINECS: | 216-074-4 |
Density: | 0.89 g/mL at 25 °C(lit.) |
Melting Point: | 34-36 °C(lit.) |
Boiling Point: | 216 °C(lit.) |
Flash Point: | 200 °F |
Hazard Symbols: | R37/38:; R41:; |
Risk Codes: | Xi:Irritant; "> Xi:Irritant; |
Safety: | 36/37/39-36-26 |
PSA: | 20.23000 |
LogP: | 2.43950 |
(1S,2R,4R)-1-Isopropyl-2-methoxymethoxy-4-methyl-cyclohexane
menthol
Conditions | Yield |
---|---|
With pyridinium p-toluenesulfonate In butanone for 3.5h; Heating; | 99% |
(1S,2R,4R)-1-Isopropyl-2-(2-methoxy-ethoxymethoxy)-4-methyl-cyclohexane
menthol
Conditions | Yield |
---|---|
With pyridinium p-toluenesulfonate In butanone for 4h; Heating; | 99% |
menthol
Conditions | Yield |
---|---|
With phosphomolybdic acid hydrate; silica gel In tetrahydrofuran at 20℃; for 0.333333h; | 96% |
menthol
Conditions | Yield |
---|---|
With palladium on activated charcoal; hydrogen In methanol at 25℃; under 2280.15 Torr; for 8h; | 95.6% |
With hydrogen In toluene at 80℃; under 15001.5 Torr; for 16h; Kinetics; Catalytic behavior; Reagent/catalyst; Autoclave; | 96 %Chromat. |
benzyl 4-nitrobenzenesulfinate
menthol
Conditions | Yield |
---|---|
With potassium hydroxide In methanol at 25℃; for 0.5h; | 93% |
(E/Z)-3,7-dimethyl-2,6-octadienal
A
Citronellol
B
tetrahydrogeraniol
menthol
Conditions | Yield |
---|---|
With hydrogen In tert-butyl alcohol at 80℃; under 1500.15 - 15001.5 Torr; for 8h; Autoclave; diastereoselective reaction; | A n/a B n/a C 89% |
allyl menthyl ether
menthol
Conditions | Yield |
---|---|
With titanium(III) chloride; magnesium In tetrahydrofuran for 2.5h; Heating; | 88% |
(E/Z)-3,7-dimethyl-2,6-octadienal
A
Citronellol
B
tetrahydrogeraniol
menthol
Conditions | Yield |
---|---|
With hydrogen In tert-butyl alcohol at 80℃; under 7500.75 Torr; for 8h; Autoclave; diastereoselective reaction; | A n/a B n/a C 87% D n/a |
menthol
Conditions | Yield |
---|---|
With ruthenium(IV) oxide In cyclohexane at 75℃; under 7500.75 Torr; for 22h; Temperature; Time; | 68% |
With hydrogen; nickel at 180℃; under 7355.08 - 22065.2 Torr; | |
With calcium ethoxide at 180℃; | |
With aluminum ethoxide at 180℃; |
(E/Z)-3,7-dimethyl-2,6-octadienal
A
tetrahydrogeraniol
B
3,7-dimethyl-1-octanal
menthol
Conditions | Yield |
---|---|
With 5%-palladium/activated carbon; hydrogen In tert-butyl alcohol at 80℃; under 1500.15 - 15001.5 Torr; for 40h; Autoclave; diastereoselective reaction; | A n/a B n/a C 68% D n/a |
1. | skn-rbt 500 mg/24H MLD | FCTXAV Food and Cosmetics Toxicology. 14 (1976),443. | ||
2. | eye-rbt 1% | FRZKAP Farmatsevtichnii Zhurnal (Kiev). 17 (3)(1962),53. | ||
3. | orl-rat LD50:2900 mg/kg | FAONAU Food and Agriculture Organization of United Nations, Report Series. 44A (1967),59. | ||
4. | scu-rat LDLo:1 g/kg | MMWOAU Muenchener Medizinische Wochenscrift. 73 (1926),2011. | ||
5. | orl-mus LD50:3100 mg/kg | QJPPAL Quarterly Journal of Pharmacy and Pharmacology. 5 (1932),233. | ||
6. | scu-mus LDLo:14 g/kg | MMWOAU Muenchener Medizinische Wochenscrift. 73 (1926),2011. | ||
7. | orl-cat LDLo:1500 mg/kg | MMWOAU Muenchener Medizinische Wochenscrift. 73 (1926),2011. | ||
8. | ipr-cat LDLo:1500 mg/kg | MMWOAU Muenchener Medizinische Wochenscrift. 73 (1926),2011. | ||
9. | ipr-rbt LDLo:2000 mg/kg | FAONAU Food and Agriculture Organization of United Nations, Report Series. 44A (1967),59. | ||
10. | ipr-gpg LD50:865 mg/kg | APFRAD Annales Pharmaceutiques Francaises. 10 (1952),481. |