Thiophene-2,5-dicarbonitrile

Base Information

• Chemical Name: Thiophene-2,5-dicarbonitrile
• CAS No.: 18853-40-2
• Molecular Formula: C6H2 N2 S
• Molecular Weight: 134.161
• Mol file: 18853-40-2.mol

Synonyms:2,5-Dicyanothiophene;

Chemical Property of Thiophene-2,5-dicarbonitrile

Chemical Property:

• Vapor Pressure: 0.0229mmHg at 25°C
• Refractive Index: 1.596
• Boiling Point: 249.5oC at 760 mmHg
• Flash Point: 104.7oC
• PSA: 75.82000
• Density: 1.34g/cm3
• LogP: 1.49146

Purity/Quality:

99% ^*data from raw suppliers

Thiophene-2,5-dicarbonitrile 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Thiophene-2,5-dicarbonitrile

There total 5 articles about Thiophene-2,5-dicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

2,5-dibromothiophen (3141-27-3) + copper(I) cyanide (544-92-3) → 2,5-thiophenedicarbonitrile (18853-40-2)

Guidance literature:

In quinoline; for 3.5h; Heating;

Reference yield:

2,5-diclorothiophene (3172-52-9,173777-89-4) + dicyanozinc (557-21-1) → 5-chlorothiophene-2-carbonitrile (50478-16-5) + 2,5-thiophenedicarbonitrile (18853-40-2)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In N,N-dimethyl acetamide; at 130 ℃; for 3h;

DOI:10.1055/s-2003-42490

Reference yield:

5-bromo-2-chlorothiophene (2873-18-9) + dicyanozinc (557-21-1) → 5-chlorothiophene-2-carbonitrile (50478-16-5) + 2,5-thiophenedicarbonitrile (18853-40-2)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In N,N-dimethyl acetamide; at 120 ℃; for 23h;

DOI:10.1055/s-2003-42490

upstream raw materials:

2,5-dibromothiophen

copper(I) cyanide

potassium cyanide

2,5-diclorothiophene

Downstream raw materials:

Thiophene-2,5-dicarboxylic acid

Refernces

• 1、 Bock, H.,Roth, B.. "RADICAL IONS 49. Redox Reactions of some Thiphene Derivatives". . p. 211 - 224. Retrieved 2007/10/02.