MK-2206 2HCl

Base Information

• Chemical Name: MK-2206 2HCl
• CAS No.: 1032350-13-2
• Molecular Formula: C₂₅H₂₁N₅O*2ClH
• Molecular Weight: 480.397
• Hs Code.: 2933998090
• Mol file: 1032350-13-2.mol

Synonyms:MK-2206

Chemical Property of MK-2206 2HCl

Chemical Property:

• PSA: 89.07000
• LogP: 6.54700
• Storage Temp.: -20°C
• Solubility.: Soluble in DMSO (up to 10 mg/ml with warming)

Purity/Quality:

99% ^*data from raw suppliers

MK-2206 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: MK-2206 (CAS 1032350-13-2) is a potent and selective allosteric inhibitor of Akt (IC50’s: Akt1 = 5 nM, Akt2 = 12 nM, Akt3 = 65 nM) that enhances the?in vitro?and?in vivo?antitumor efficacy of several standard chemotherapeutic agents.1?It was able to decrease insulin-stimulated glucose uptake, glycogen synthesis and glycogen synthase activity in rat muscle.2?MK-2206 induced G1-phase cycle arrest and sensitized HepG2 hepatocellular carcinoma cells to TRAIL-induced apoptosis.3
• Uses: AZD 6244 and MK 2206 are targeted small-molecule drugs that inhibit MEK and AKT responses. The combination of AZD6244 and MK2206 has a significant synergistic effect on tumor growth in vitro and in vi vo and leads to increased survival rates in mice bearing highly aggressive human lung tumors. Antitumor agents. AZD 6244 and MK 2206 are targeted small-molecule drugs that inhibit MEK and AKT responses. The combination of AZD6244 and MK2206 has a significant synergistic effect on tumor growth in vitro and in vivo and leads to increased survival rates in mice bearing highly aggressive human lung tumors. Antitumor agents. Potent AKT inhibitor.

Technology Process of MK-2206 2HCl

There total 3 articles about MK-2206 2HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl {1-[4-(3-oxo-9-phenyl-2,3-dihydro[1,2,4]triazolo[3,4-f][1,6]naphthyridin-8-yl)phenyl]cyclobutyl}carbamate → MK-2206 (1032350-13-2)

Guidance literature:

tert-butyl {1-[4-(3-oxo-9-phenyl-2,3-dihydro[1,2,4]triazolo[3,4-f][1,6]naphthyridin-8-yl)phenyl]cyclobutyl}carbamate; With hydrogenchloride; In ethanol; water; at 50 ℃; for 3h;

With acetyl chloride; In ethanol; at 0 - 20 ℃; for 1.5h;

Reference yield:

tert-butyl (2-chloro-3-formylpyridin-4-yl)carbamate (893423-62-6) → MK-2206 (1032350-13-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 20 - 35 °C / Cooling

2.1: potassium hydroxide / isopropyl alcohol / 1 h / 24 °C

3.1: hydrogenchloride / isopropyl alcohol / 16 h / 66 - 70 °C / Cooling

4.1: hydrogenchloride / water; ethanol / 3 h / 50 °C

4.2: 1.5 h / 0 - 20 °C

With hydrogenchloride; trifluoroacetic acid; potassium hydroxide; In ethanol; dichloromethane; water; isopropyl alcohol;

Reference yield:

4-amino-2-chloronicotinaldehyde (338452-92-9) → MK-2206 (1032350-13-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium hydroxide / isopropyl alcohol / 1 h / 24 °C

2.1: hydrogenchloride / isopropyl alcohol / 16 h / 66 - 70 °C / Cooling

3.1: hydrogenchloride / water; ethanol / 3 h / 50 °C

3.2: 1.5 h / 0 - 20 °C

With hydrogenchloride; potassium hydroxide; In ethanol; water; isopropyl alcohol;

upstream raw materials:

tert-butyl (2-chloro-3-formylpyridin-4-yl)carbamate

4-amino-2-chloronicotinaldehyde

Refernces