4-amino-2-chloronicotinaldehyde

Base Information

• Chemical Name: 4-amino-2-chloronicotinaldehyde
• CAS No.: 338452-92-9
• Molecular Formula: C6H5ClN2O
• Molecular Weight: 156.5697
• Hs Code.: 2933399090
• Mol file: 338452-92-9.mol

Synonyms:4-amino-2-chloronicotinaldehyde;4-Amino-2-chloro-3-pyridinecarboxaldehyde

Chemical Property of 4-amino-2-chloronicotinaldehyde

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 370.675°C at 760 mmHg
• PKA: 2.58±0.42(Predicted)
• Flash Point: 177.978°C
• PSA: 55.98000
• Density: 1.442g/cm³
• LogP: 1.71090
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99.0% ^*data from raw suppliers

4-amino-2-chloronicotinaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-amino-2-chloronicotinaldehyde is a useful research chemical.

Technology Process of 4-amino-2-chloronicotinaldehyde

There total 4 articles about 4-amino-2-chloronicotinaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl (2-chloro-3-formylpyridin-4-yl)carbamate (893423-62-6) → 4-amino-2-chloronicotinaldehyde (338452-92-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 6h;

Reference yield:

(2-chloro-pyridin-4-yl)-carbamic acid tert-butyl ester (234108-73-7) → 4-amino-2-chloronicotinaldehyde (338452-92-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium tert-butyl / tetrahydrofuran / 0.5 h / -78 °C

1.2: 2 h / -78 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

With lithium tert-butyl; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

4-Amino-2-chloropyridine (14432-12-3) → 4-amino-2-chloronicotinaldehyde (338452-92-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine; dmap / dichloromethane / 2 h / 0 - 20 °C

2.1: lithium tert-butyl / tetrahydrofuran / 0.5 h / -78 °C

2.2: 2 h / -78 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

With dmap; lithium tert-butyl; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

upstream raw materials:

tert-butyl (2-chloro-3-formylpyridin-4-yl)carbamate

(2-chloro-pyridin-4-yl)-carbamic acid tert-butyl ester

4-Amino-2-chloropyridine

Downstream raw materials:

tert-butyl {1-[4-(5-chloro-3-phenyl-1,6-naphthyrindin-2-yl)phenyl]cyclobutyl}carbamate

MK-2206

Refernces

• 1、 -. "IL-23 ANTAGONISTS FOR TREATMENT OR PREVENTION OF SKIN RASH ASSOCIATED WITH TREATMENT WITH P13K/AKT PATHWAY INHIBITORS". Paragraph 00183. . Retrieved 2013/03/26.