4-Chloro-2,5-difluoronitrobenzene

Base Information

• Chemical Name: 4-Chloro-2,5-difluoronitrobenzene
• CAS No.: 578-28-9
• Molecular Formula: C6H2ClF2NO2
• Molecular Weight: 193.537
• Hs Code.: 2904909090
• Mol file: 578-28-9.mol

Synonyms:1-chloro-2,5-difluoro-4-nitrobenzene;

Chemical Property of 4-Chloro-2,5-difluoronitrobenzene

Chemical Property:

• Vapor Pressure: 0.039mmHg at 25°C
• Boiling Point: 248.1oC at 760 mmHg
• Flash Point: 103.8oC
• PSA: 45.82000
• Density: 1.591g/cm3
• LogP: 3.04960
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

1-Chloro-2,5-difluoro-4-nitrobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Chloro-2,5-difluoronitrobenzene

There total 3 articles about 4-Chloro-2,5-difluoronitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-chloro-2,5-difluorobenzene (2367-91-1) → 1-Chloro-2,5-difluoro-4-nitrobenzene (578-28-9)

Guidance literature:

With sulfuric acid; nitric acid; at -40 - 20 ℃;

DOI:10.1002/ejoc.202100603

Reference yield:

para-difluorobenzene (540-36-3) → 1-Chloro-2,5-difluoro-4-nitrobenzene (578-28-9)

Guidance literature:

With sodium hydroxide; conc. HNO₃; sulfuric acid; In water;

Reference yield:

2,5-difluoro-4-nitroaniline (1542-36-5) → 1-Chloro-2,5-difluoro-4-nitrobenzene (578-28-9)

Guidance literature:

With hydrogenchloride; sodium nitrite; anschliessendes Behandeln mit Kupfer(I)-chlorid und konz. wss. Salzsaeure;

DOI:10.1021/ja01592a073

upstream raw materials:

2,5-difluoro-4-nitroaniline

1-chloro-2,5-difluorobenzene

para-difluorobenzene

Downstream raw materials:

4-chloro-2,5-difluoroaniline

N-(5'-chloro-4'-fluoro-2'-nitrophenyl)glycine sodium salt

Refernces

• 1、 -. "FUSED PENTACYCLIC IMIDAZOLE DERIVATIVES". Page/Page column 151. . Retrieved 2016/04/26.
• 2、 -. "Substituted benzene compounds, process for their preparation, and herbicidal and defoliant compositions containing them". . . Retrieved 2008/06/13.