1-Chloro-2,5-difluorobenzene

Base Information

• Chemical Name: 1-Chloro-2,5-difluorobenzene
• CAS No.: 2367-91-1
• Molecular Formula: C6H3ClF2
• Molecular Weight: 148.54
• Hs Code.: 2903999090
• Mol file: 2367-91-1.mol

Synonyms:1,4-Difluoro-2-chlorobenzene;2,5-Difluorochlorobenzene;2-Chloro-1,4-difluorobenzene;NSC 10253;

Chemical Property of 1-Chloro-2,5-difluorobenzene

Chemical Property:

• Appearance/Colour: liquid
• Melting Point: 24.6 °C
• Refractive Index: n20/D 1.478(lit.)
• Boiling Point: 134.2 °C at 760 mmHg
• Flash Point: 33 °C
• PSA: 0.00000
• Density: 1.352 g/cm³
• LogP: 2.61820
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

1-Chloro-2,5-difluorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, F, Xi
• Hazard Codes: Xn,F,Xi
• Statements: 10-20/21/22-36/37-36/37/38-11
• Safety Statements: 16-26-36-37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Chloro-2,5-difluorobenzene

There total 5 articles about 1-Chloro-2,5-difluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

para-difluorobenzene (540-36-3) → 1-chloro-2,5-difluorobenzene (2367-91-1)

Guidance literature:

With N-chloro-succinimide; boron trifluoride; at 20 ℃; for 24h;

Reference yield:

chlorobenzene (108-90-7) → 1-chloro-2-fluorobenzene (348-51-6) + 1-Chloro-4-fluorobenzene (352-33-0) + 3-chlorofluorobenzene (625-98-9) + 1-chloro-2,4-difluorobenzene (1435-44-5) + 4-chloro-1,2-difluorobenzene (696-02-6) + 1-chloro-2,5-difluorobenzene (2367-91-1)

Guidance literature:

With xenon difluoride; boron trifluoride diethyl etherate; at 0 - 25 ℃; Reagent/catalyst; Cooling with ice;

DOI:10.1134/S1070428016100055

Reference yield:

tetrafluoroborate salt + 3-chloro-4-fluorophenylamine (367-21-5) + diethyl ether (60-29-7,927820-24-4) → 1-chloro-2,5-difluorobenzene (2367-91-1)

Guidance literature:

With tetrafluoroboric acid; sodium nitrite; In methanol; salt 3-chloro-4-fluorobenzenediazonium tetrafluoroborate; water;

upstream raw materials:

para-difluorobenzene

3-chloro-4-fluorophenylamine

diethyl ether

chlorobenzene

Downstream raw materials:

ethyl (4-chloro-3,6-difluoro-2-nitrophenyl)carbamate

2-(2,5-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Refernces

• 1、 Prakash, G. K. Surya,Mathew, Thomas,Hoole, Dushyanthi,Esteves, Pierre M.,Wang, Qi,Rasul, Golam,Olah, George A.. "N-halosuccinimide/BF3-H2O, efficient electrophilic halogenating systems for aromatics". . p. 15770 - 15776. Retrieved 2007/10/03.
• 2、 -. "Procedure for the preparation of N-cyclopropyl-4-fluoroanilines". . . Retrieved 2008/06/13.