C₂₀H₂₄INO₅

Base Information

• Chemical Name: C₂₀H₂₄INO₅
• CAS No.: 1430104-98-5
• Molecular Formula: C₂₀H₂₄INO₅
• Molecular Weight: 485.319
• Mol file: 1430104-98-5.mol

Synonyms:C₂₀H₂₄INO₅

Chemical Property of C₂₀H₂₄INO₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₂₄INO₅

There total 11 articles about C₂₀H₂₄INO₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(6S)-5-[(tert-butoxy)carbonyl]-5-azaspiro[2.4]heptane-6-carboxylic acid (1129634-44-1,1454843-77-6,1454843-78-7) + 2-bromo-1-(4-iodophenyl)ethanone (31827-94-8) → C20H24INO5 (1430104-98-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 3h;

Reference yield:

(S)-Pyroglutaminol (17342-08-4) → C20H24INO5 (1430104-98-5)

Guidance literature:

Multi-step reaction with 9 steps

1.1: toluene-4-sulfonic acid / toluene / Reflux; Dean-Stark

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -50 - -40 °C

2.2: 0.5 h / -55 - -45 °C

3.1: potassium hydrogencarbonate / methanol; water / 10 - 50 °C

4.1: potassium tert-butylate / tetrahydrofuran / 1 h / 10 - 60 °C

4.2: 10 - 60 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 50 - 60 °C

6.1: palladium 10% on activated carbon; ammonium formate / methanol; water / 10 - 50 °C / Inert atmosphere

7.1: dichloromethane / 20 - 45 °C

7.2: 20 °C

8.1: Jones reagent / acetone / 2 h / 0 - 37 °C

9.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.25 h / 20 °C

With lithium aluminium tetrahydride; Jones reagent; palladium 10% on activated carbon; potassium tert-butylate; ammonium formate; potassium hydrogencarbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water; acetone; toluene; acetonitrile;

Reference yield:

((S)-(5-benzyl-5-azaspiro[2.4]heptan-6-yl)methanol) (1431322-85-8) → C20H24INO5 (1430104-98-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: palladium 10% on activated carbon; ammonium formate / methanol; water / 10 - 50 °C / Inert atmosphere

2.1: dichloromethane / 20 - 45 °C

2.2: 20 °C

3.1: Jones reagent / acetone / 2 h / 0 - 37 °C

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.25 h / 20 °C

With Jones reagent; palladium 10% on activated carbon; ammonium formate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; water; acetone; acetonitrile;

upstream raw materials:

(3R,7aS)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one

(3R,7aS)-6-methylene-3-phenyltetrahydropyrrolo[1,2-c]oxazol-5(1H)-one

(3’R,7a’S)-3’-phenyldihydro-1‘H-spiro[cyclopropane-1,6’-pyrrolo[1,2-c][1,3]oxazol]-5’-one

((S)-(5-benzyl-5-azaspiro[2.4]heptan-6-yl)methanol)

Downstream raw materials:

(S)-tert-butyl 6-(5-(4-iodophenyl)-1H-imidazol-2-yl)-5-azaspiro[2.4]heptane-5-carboxylate

Refernces

• 1、 -. "PROCESSES FOR THE PREPARATION OF NOVEL BENZIMIDAZOLE DERIVATIVES". . . Retrieved 2013/05/09.