CYCLOHEXYLHYDRAZINE HYDROCHLORIDE

Base Information

• Chemical Name: CYCLOHEXYLHYDRAZINE HYDROCHLORIDE
• CAS No.: 24214-73-1
• Molecular Formula: C6H14N2^.HCl
• Molecular Weight: 150.651
• Hs Code.: 29280000
• Mol file: 24214-73-1.mol

Synonyms:Hydrazine,cyclohexyl-, monohydrochloride (8CI,9CI);Cyclohexylhydrazine monohydrochloride;

Chemical Property of CYCLOHEXYLHYDRAZINE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.188mmHg at 25°C
• Melting Point: 110-114 °C(lit.)
• Boiling Point: 210.9 °C at 760 mmHg
• Flash Point: 91.7 °C
• PSA: 38.05000
• LogP: 2.67560
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Water Solubility.: almost transparency

Purity/Quality:

98% ^*data from raw suppliers

Cyclohexylhydrazine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CYCLOHEXYLHYDRAZINE HYDROCHLORIDE

There total 8 articles about CYCLOHEXYLHYDRAZINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N'-cyclohexyl-hydrazine carboxylic acid tert-butyl ester (60295-21-8) → cyclohexylhydrazine hydrochloride (24214-73-1,30929-57-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; Reflux;

Reference yield: 93.0%

tert-butyl 2-cyclohexylidenehydrazine-1-carboxylate (60295-11-6) → cyclohexylhydrazine hydrochloride (24214-73-1,30929-57-8)

Guidance literature:

tert-butyl 2-cyclohexylidenehydrazine-1-carboxylate; With sodium cyanoborohydride; In tetrahydrofuran; methanol; at 20 ℃;

With hydrogenchloride; water; In tetrahydrofuran; ethanol; for 1h; Heating / reflux;

Reference yield: 42.0%

cyclohexylmagnesiumchloride (931-51-1) → cyclohexylhydrazine hydrochloride (24214-73-1,30929-57-8)

Guidance literature:

cyclohexylmagnesiumchloride; With dinitrogen monoxide; In tetrahydrofuran; for 3h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; water; Inert atmosphere;

DOI:10.1021/om500333y

upstream raw materials:

N'-cyclohexyl-hydrazine carboxylic acid tert-butyl ester

tert-butyl 2-cyclohexylidenehydrazine-1-carboxylate

cyclohexanone

cyclohexylmagnesiumchloride

Downstream raw materials:

cyclohexylthiosemicarbazide

5-amino-3-(p-chlorophenyl)-4-cyano-1-cyclohexylpyrazole

1-(cyclohexyl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

1,5-dicyclohexyl-4-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

Refernces

• 1、 Yatham, Veera Reddy,Bellotti, Peter,K?nig, Burkhard. "Decarboxylative hydrazination of unactivated carboxylic acids by cerium photocatalysis". supporting information. p. 3489 - 3492. Retrieved 2019/03/26.
• 2、 -. "INHIBITORS OF BRUTON'S TYROSINE KINASE". Paragraph 0419. . Retrieved 2014/06/23.