Tert-butyl 2-cyclohexylidenehydrazinecarboxylate

Base Information

• Chemical Name: Tert-butyl 2-cyclohexylidenehydrazinecarboxylate
• CAS No.: 60295-11-6
• Molecular Formula: C11H20N2O2
• Molecular Weight: 212.292
• Hs Code.: 2928000090
• DSSTox Substance ID: DTXSID90401103
• Mol file: 60295-11-6.mol

Synonyms:60295-11-6;tert-butyl 2-cyclohexylidenehydrazinecarboxylate;tert-butyl N-(cyclohexylideneamino)carbamate;tert-Butyl 2-cyclohexylidenehydrazine-1-carboxylate;HYDRAZINECARBOXYLIC ACID, 2-CYCLOHEXYLIDENE-, 1,1-DIMETHYLETHYL ESTER;MFCD00447802;N'-cyclohexylidene(tert-butoxy)carbohydrazide;SCHEMBL12779155;1-Boc-2-cyclohexylidenehydrazine;DTXSID90401103;VBSQBVWEZOIWGF-UHFFFAOYSA-N;CS-D0140;AKOS001700293;AM81193;AS-42118;SY125534;tert-butyl2-cyclohexylidenehydrazinecarboxylate;SR-01000089130;SR-01000089130-1;2-Cyclohexylidene-hydrazinecarboxylic acid 1,1-dimethylethyl ester

Chemical Property of Tert-butyl 2-cyclohexylidenehydrazinecarboxylate

Chemical Property:

• PSA: 54.18000
• LogP: 3.03560
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 212.152477885
• Heavy Atom Count: 15
• Complexity: 246

Purity/Quality:

99% ^*data from raw suppliers

tert-butylN-(cyclohexylideneamino)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NN=C1CCCCC1

Technology Process of Tert-butyl 2-cyclohexylidenehydrazinecarboxylate

There total 2 articles about Tert-butyl 2-cyclohexylidenehydrazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

t-butoxycarbonylhydrazine (870-46-2) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → tert-butyl 2-cyclohexylidenehydrazine-1-carboxylate (60295-11-6)

Guidance literature:

In hexane; for 0.333333h; Heating;

DOI:10.1021/jo00339a035

Reference yield:

N-(tert-butyloxycarbonyl) azide (1070-19-5) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → tert-butyl 2-cyclohexylidenehydrazine-1-carboxylate (60295-11-6)

Guidance literature:

In ethanol;

DOI:10.1021/jo00886a007

Reference yield: 93.0%

tert-butyl 2-cyclohexylidenehydrazine-1-carboxylate (60295-11-6) → cyclohexylhydrazine hydrochloride (24214-73-1,30929-57-8)

Guidance literature:

tert-butyl 2-cyclohexylidenehydrazine-1-carboxylate; With sodium cyanoborohydride; In tetrahydrofuran; methanol; at 20 ℃;

With hydrogenchloride; water; In tetrahydrofuran; ethanol; for 1h; Heating / reflux;

upstream raw materials:

N-(tert-butyloxycarbonyl) azide

cyclohexanone

t-butoxycarbonylhydrazine

Downstream raw materials:

N'-cyclohexyl-hydrazine carboxylic acid tert-butyl ester

cyclohexylhydrazine hydrochloride

1-(cyclohexyl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

1,5-dicyclohexyl-4-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

Refernces

• 1、 -. "PYRAZOLOPYRIMIDINES AS INHIBITORS OF GLUCOCORTICOID RECEPTOR TRANSLOCATION". Paragraph 00475. . Retrieved 2016/08/23.
• 2、 Nun, Pierrick,Martin, Charlotte,Martinez, Jean,Lamaty, Frédéric. "Solvent-free synthesis of hydrazones and their subsequent N-alkylation in a Ball-mill". supporting information; experimental part. p. 8187 - 8194. Retrieved 2011/10/31.