diethyl (1-phenylethyl)phosphoramidate

Base Information

• Chemical Name: diethyl (1-phenylethyl)phosphoramidate
• CAS No.: 85231-78-3
• Molecular Formula: C₁₂H₂₀NO₃P
• Molecular Weight: 257.269
• Mol file: 85231-78-3.mol

Synonyms:diethyl (1-phenylethyl)phosphoramidate

Chemical Property of diethyl (1-phenylethyl)phosphoramidate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl (1-phenylethyl)phosphoramidate

There total 3 articles about diethyl (1-phenylethyl)phosphoramidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

phosphonic acid diethyl ester (762-04-9) + rac-methylbenzylamine (618-36-0) → diethyl (1-phenylethyl)phosphoramidate (85231-78-3)

Guidance literature:

With tetrachloromethane; triethylamine; In ethanol; at 0 - 20 ℃; for 5h;

DOI:10.1002/anie.202014955

Reference yield:

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + Diethyl phosphoramidate (1068-21-9) → diethyl (1-phenylethyl)phosphoramidate (85231-78-3)

Guidance literature:

With sodium hydroxide; sodium tetrahydroborate; mercury(II) nitrate; Yield given. Multistep reaction; 1.) CH₃CHCl₂, reflux, 8 h, 2.) room temp., 1 h;

DOI:10.1055/s-1982-29995

Reference yield:

N-(Diethoxyphosphoryl)benzylideneimine (180399-94-4) + methyl iodide (74-88-4) → diethyl (1-phenylethyl)phosphoramidate (85231-78-3)

Guidance literature:

With magnesium; Yield given; Multistep reaction; 1.) THF, 40-45 deg C, 2.) THF, 20-25 deg C, 2 h;

DOI:10.1055/s-1999-3496

upstream raw materials:

styrene

Diethyl phosphoramidate

phosphonic acid diethyl ester

rac-methylbenzylamine

Downstream raw materials:

Fe(CO)4CNCH(CH₃)C₆H₅

(α)-methylbenzylamine hydrochloride

Refernces

• 1、 Zwierzak, Andrzej,Napieraj, Anna. "Synthesis of α-arylalkylamines by addition of Grignard reagents to N- (diethoxyphosphoryl)aldimines". . p. 930 - 934. Retrieved 2007/10/03.
• 2、 Koziara, Anna,Olejniczak, Bogdan,Osowska, Krystyna,Zwierzak, Andrzej. "Phosphoramidomercuration-Demercuration: A Simple, Two-Step Conversion of Alkenes into Alkanamines". . p. 918 - 920. Retrieved 2007/10/02.