DIETHYL PHOSPHORAMIDATE

Base Information

• Chemical Name: DIETHYL PHOSPHORAMIDATE
• CAS No.: 1068-21-9
• Molecular Formula: C4H12NO3P
• Molecular Weight: 153.118
• Hs Code.: 2929909090
• Mol file: 1068-21-9.mol

Synonyms:Diethyl Phosphoramidate;Amidophosphoric acid diethyl ester;

Chemical Property of DIETHYL PHOSPHORAMIDATE

Chemical Property:

• Vapor Pressure: 0.000652mmHg at 25°C
• Melting Point: 51-53 °C(lit.)
• Refractive Index: 1.424
• Boiling Point: 309.1 °C at 760 mmHg
• PKA: 0.52±0.70(Predicted)
• Flash Point: 140.7 °C
• PSA: 71.36000
• Density: 1.133 g/cm³
• LogP: 1.82650
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

Diethylphosphoramidatea ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Diethyl Phosphoramidate is an inhibitor of cholinesterase. It is toxic to houseflies and are used in insecticidal preparations. It also exhibits herbicidal and hydrolytic properties. Diethyl phosphoramidate may be employed as reagent which mimics or imitates the actual chemical warfare agents. It may be used in the preparation of α-aminoalkyl phosphonates, via three-component Mannich type reaction.

Technology Process of DIETHYL PHOSPHORAMIDATE

There total 42 articles about DIETHYL PHOSPHORAMIDATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

Diethyl phosphonate (762-04-9,123-22-8) → Diethyl phosphoramidate (1068-21-9)

Guidance literature:

With ammonia; In tetrachloromethane; 1.) 15-20 deg C, 2.) room temperature, 0.5 h;

DOI:10.1016/S0040-4020(01)82369-3

Reference yield: 87.0%

diethyl chlorophosphate (814-49-3) → Diethyl phosphoramidate (1068-21-9)

Guidance literature:

With ammonia; triethylamine; In diethyl ether; at -35 ℃; for 1h;

DOI:10.1016/j.ejmech.2004.01.006

Reference yield: 83.0%

phosphonic acid diethyl ester (762-04-9) → Diethyl phosphoramidate (1068-21-9)

Guidance literature:

With iodoform; ammonia; at -33 ℃;

DOI:10.1081/SCC-120026306

upstream raw materials:

diethyl ether

O,O,O-triethyl phosphorothioate

triphosphoric acid pentaethyl ester

diethyl chlorophosphate

Downstream raw materials:

N-(β-Cyan-styryl)-O.O-diethyl-phosphorsaeureamid

diethyl N-sulfinylphosphoramidate

N²-(diethoxyphosphinyl)-N¹-phenylthiourea

diethyl (1-phenylethyl)phosphoramidate

Refernces

• 1、 Zwierzak,A.,Koziara,A.. "-". . p. 3521 - 3525. Retrieved 1970.
• 2、 Malowan. "-". . p. 78,79. Retrieved 1953.
• 3、 Mielniczak, Grazyna,Lopusinski, Andrzej. "Oxidation of diethyl N-sulfinylphosphoramidates". . p. 530 - 536. Retrieved 2008/12/22.
• 4、 Grison, Claude,Coutrot, Philippe,Comoy, Corinne,Balas, Laurence,Joliez, Stephane,Lavecchia, Guido,Oliger, Patrick,Penverne, Bernadette,Serre, Valerie,Herve, Guy. "Design, synthesis and activity of bisubstrate, transition-state analogues and competitive inhibitors of aspartate transcarbamylase". . p. 333 - 344. Retrieved 2007/10/03.