C₁₂H₁₂Br₂O₃

Base Information

• Chemical Name: C₁₂H₁₂Br₂O₃
• CAS No.: 1320346-37-9
• Molecular Formula: C₁₂H₁₂Br₂O₃
• Molecular Weight: 364.033
• Mol file: 1320346-37-9.mol

Synonyms:C₁₂H₁₂Br₂O₃

Chemical Property of C₁₂H₁₂Br₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₂H₁₂Br₂O₃

There total 2 articles about C₁₂H₁₂Br₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-carbomethoxyphenyl)butanal (106200-41-3) → C12H12Br2O3 (1320346-37-9)

Guidance literature:

With hydrogen bromide; bromine; acetic acid; In dichloromethane; Reflux;

DOI:10.1016/j.tetlet.2011.05.141

Reference yield:

4-methoxycarbonylphenyl bromide (619-42-1) → C12H12Br2O3 (1320346-37-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: copper(l) iodide; diethylamine; triphenylphosphine; palladium dichloride / 4 h / 50 °C

1.2: 3.5 h / 2585.81 Torr

1.3: 1 h / -10 - 0 °C

2.1: hydrogen bromide; bromine; acetic acid / dichloromethane / Reflux

With copper(l) iodide; hydrogen bromide; bromine; acetic acid; diethylamine; triphenylphosphine; palladium dichloride; In dichloromethane;

DOI:10.1016/j.tetlet.2011.05.141

Reference yield: 85.0%

C12H12Br2O3 (1320346-37-9) + 2,6-diaminopyrimidin-4-ol (56-06-4) → methyl 4-[2-(2-amino-4,6-dioxo-4,5,6,7-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoate (1320346-43-7)

Guidance literature:

C₁₂H₁₂Br₂O₃; 2,6-diaminopyrimidin-4-ol; In water; acetonitrile; for 0.0833333h;

With sodium acetate; In water; acetonitrile; Reflux;

DOI:10.1016/j.tetlet.2011.05.141

upstream raw materials:

4-methoxycarbonylphenyl bromide

4-(4-carbomethoxyphenyl)butanal

Downstream raw materials:

4-[2-(2-amino-4,6-dioxo-4,5,6,7-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoic acid

dimethyl 2-{4-[2-(2-amino-4,6-dioxo-4,5,6,7-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-pentanedioate

2-{4-[2-(2-amino-4,6-dioxo-4,5,6,7-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-pentanedioic acid

methyl 4-[2-(2-amino-4,6-dioxo-4,5,6,7-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoate

Refernces