1320346-43-7

Basic information

• Product Name: 4-[2-(2-AMino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoic Acid Methyl Ester
• Synonyms: 4-[2-(2-AMino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoic Acid Methyl Ester
• CAS NO: 1320346-43-7
• Molecular Formula: C₁₆H₁₆N₄O₄
• Molecular Weight: 328.32264
• Product Categories: Aromatics, Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1320346-43-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: DMSO, Methanol
• CAS DataBase Reference: 4-[2-(2-AMino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoic Acid Methyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-(2-AMino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoic Acid Methyl Ester(1320346-43-7)
• EPA Substance Registry System: 4-[2-(2-AMino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoic Acid Methyl Ester(1320346-43-7)

Safety Data

• Hazardous Substances Data: 1320346-43-7(Hazardous Substances Data)

Usage

Chemical Properties

Pink Solid

Uses

Used in the preparation of a Pemetrexed (P219500) metabolite.

Upstream product

• 106200-41-3 4-(4-carbomethoxyphenyl)butanal 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 1320346-37-9 C₁₂H₁₂Br₂O₃ 
• 56-06-4 2,6-diaminopyrimidin-4-ol 

Downstream Products

• 193265-47-3 4-[2-(2-amino-4,6-dioxo-4,5,6,7-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoic acid 
• 1320346-45-9 dimethyl 2-{4-[2-(2-amino-4,6-dioxo-4,5,6,7-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-pentanedioate 
• 193281-00-4 2-{4-[2-(2-amino-4,6-dioxo-4,5,6,7-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-pentanedioic acid 

Relevant articles and documents

A short and efficient synthetic protocol for the synthesis of 5-substituted-4,6-dioxo-pyrrolo[2,3-d]pyrimidines

A short and efficient synthesis for 5-substituted-4,6-dioxo-pyrrolo[2,3-d] pyrimidines has been developed by the cyclocondensation of α,α- dibromoaldehydes with 2,4-diamino-6-hydroxypyrimidine under mild basic conditions in good yields. Application of this protocol has been demonstrated in the synthesis of a metabolite of Pemetrexed disodium, a novel multi-targeted antifolate.