2-(o-fluorophenyl)-1(2H)-phthalazinone

Base Information

• Chemical Name: 2-(o-fluorophenyl)-1(2H)-phthalazinone
• CAS No.: 103286-26-6
• Molecular Formula: C₁₄H₉FN₂O
• Molecular Weight: 240.237
• Mol file: 103286-26-6.mol

Synonyms:2-(o-fluorophenyl)-1(2H)-phthalazinone

Chemical Property of 2-(o-fluorophenyl)-1(2H)-phthalazinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(o-fluorophenyl)-1(2H)-phthalazinone

There total 5 articles about 2-(o-fluorophenyl)-1(2H)-phthalazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.3%

3-hydroxy-1(3H)-isobenzofuranone (16859-59-9) + (2-fluorophenyl)hydrazine hydrochloride (2924-15-4) → 2-(o-fluorophenyl)-1(2H)-phthalazinone (103286-26-6)

Guidance literature:

DOI:10.1248/cpb.33.2809

Reference yield: 65.0%

carbon monoxide (201230-82-2) + 2-formylphenyl tosylate (19820-56-5) + (2-fluorophenyl)hydrazine hydrochloride (2924-15-4) → 2-(o-fluorophenyl)-1(2H)-phthalazinone (103286-26-6)

Guidance literature:

With palladium(II) trifluoroacetate; 1,3-bis-(diphenylphosphino)propane; magnesium sulfate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 150 ℃; for 21h; under 7500.75 Torr; Autoclave;

DOI:10.1016/j.tet.2016.10.065

Reference yield: 62.5%

dicobalt octacarbonyl (15226-74-1,61091-28-9,61117-58-6) + (2-fluorophenyl)hydrazine hydrochloride (2924-15-4) + ortho-bromobenzaldehyde (6630-33-7) → 2-(o-fluorophenyl)-1(2H)-phthalazinone (103286-26-6)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 90 ℃; for 3h; Sealed tube; Molecular sieve;

DOI:10.1016/j.tetlet.2014.04.082

upstream raw materials:

3-hydroxy-1(3H)-isobenzofuranone

(2-fluorophenyl)hydrazine hydrochloride

o-carboxybenzaldehyde

dicobalt octacarbonyl

Refernces

• 1、 Liu, Bin,Zhang, Chunlei,Zhou, Xigeng. "Access to phthalazinones via palladium-catalyzed three-component cycloamino-carbonylation of 2-formylaryl tosylates, hydrazines and CO". supporting information. p. 8282 - 8286. Retrieved 2016/12/02.
• 2、 Sugimoto,Sakamoto,Fujino,Takashima,Ishikawa. "Synthesis and inhibitory effect on platelet aggregation of 2-phenyl-1(2H)-phthalazinone derivatives". . p. 2809 - 2820. Retrieved 2007/10/02.