2-Fluorophenylhydrazine hydrochloride

Base Information

• Chemical Name: 2-Fluorophenylhydrazine hydrochloride
• CAS No.: 2924-15-4
• Molecular Formula: C6H8ClFN2
• Molecular Weight: 162.594
• Hs Code.: 29280000
• European Community (EC) Number: 220-885-9
• NSC Number: 158012
• DSSTox Substance ID: DTXSID00951846
• Mol file: 2924-15-4.mol

Synonyms:2-Fluorophenylhydrazine hydrochloride;2924-15-4;(2-fluorophenyl)hydrazine Hydrochloride;2-Fluorophenylhydrazine HCl;MFCD00012927;Hydrazine, (2-fluorophenyl)-, monohydrochloride;(2-Fluorophenyl)hydrazine, HCl;2-fluorophenylhydrazinehydrochloride;o-fluorophenylhydrazine hydrochloride;(2-fluorophenyl)hydrazine;hydrochloride;EINECS 220-885-9;N(N)c1ccccc1F;1-(2-fluorophenyl)hydrazine hydrochloride;SCHEMBL304797;DTXSID00951846;VFZYLSYYMHFPSY-UHFFFAOYSA-N;NSC158012;(2-fluorophenyl)hydrazineHydrochloride;2-fluoro-phenylhydrazine hydrochloride;2-fluorophenyl hydrazine hydrochloride;AKOS005254514;2-fluoro-phenyl-hydrazine hydrochloride;AM86839;CS-W016106;GS-6787;NSC-158012;SB76538;AC-16606;BP-10020;SY022145;(2-fluoro-phenyl)-hydrazine, hydrochloride;2-Fluorophenylhydrazine hydrochloride, 97%;F0368;FT-0612450;FT-0612451;Hydrazine, (2-fluorophenyl)-, hydrochloride;EN300-34689;Hydrazine, (o-fluorophenyl)-, monohydrochloride;(2-Fluorophenyl)hydrazine--hydrogen chloride (1/1);Hydrazine, (2-fluorophenyl)-, hydrochloride (1:1);J-509518;F0001-0910;Z220383458

Chemical Property of 2-Fluorophenylhydrazine hydrochloride

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 0.182mmHg at 25°C
• Melting Point: 200-205 °C (dec.)(lit.)
• Boiling Point: 211.5 °C at 760 mmHg
• Flash Point: 81.7 °C
• PSA: 38.05000
• Density: 1.257g/cm3
• LogP: 2.68660
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 162.0360041
• Heavy Atom Count: 10
• Complexity: 87.1

Purity/Quality:

99% ^*data from raw suppliers

2-Fluorophenylhydrazine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,Xi,T
• Hazard Codes: Xn,Xi,T
• Statements: 20/21/22-36/37/38-43-40-23/24/25
• Safety Statements: 26-37/39-36/37/39-45-36/37-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)NN)F.Cl
• Uses: 2-Fluorophenylhydrazine hydrochloride was used in the preparation of pyrazole derivatives.

Technology Process of 2-Fluorophenylhydrazine hydrochloride

There total 1 articles about 2-Fluorophenylhydrazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Fluoroaniline (348-54-9) → (2-fluorophenyl)hydrazine hydrochloride (2924-15-4)

Guidance literature:

With diazotizing agent; tin(ll) chloride; Multistep reaction;

DOI:10.1002/ardp.19943270208

Reference yield: 100.0%

(2-fluorophenyl)hydrazine hydrochloride (2924-15-4) + Ethoxymethylenemalononitrile (123-06-8) → 5-amino-1-(2-fluorophenyl)-1H-pyrazole-4-carbonitrile (135108-48-4)

Guidance literature:

With triethylamine; In ethanol; at 20 ℃; for 1.5h; Reflux; Inert atmosphere;

DOI:10.1021/jm100095x

Reference yield: 91.0%

2-bromo-6-fluorobenzaldehyde (360575-28-6) + (2-fluorophenyl)hydrazine hydrochloride (2924-15-4) → 4-bromo-1-(2-fluorophenyl)-1H-indazole

Guidance literature:

With caesium carbonate; In 1-methyl-pyrrolidin-2-one; at 140 ℃; for 1h;

DOI:10.1021/acs.jmedchem.6b00063

upstream raw materials:

2-Fluoroaniline

Downstream raw materials:

2-(o-fluorophenyl)-1(2H)-phthalazinone

mesoaldehyde 1,3-dioxime-2-(o-fluorophenyl)hydrazone

7-carboxy-2-(o-fluorophenyl)-1(2H)-phthalazinone

1-(2-fluorophenyl)-4-methyl-5-(4-methoxyphenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

Refernces

• 1、 Zhao, Dongbing,Shi, Zhuangzhi,Glorius, Frank. "Indole synthesis by rhodium(III)-catalyzed hydrazine-directed C-H activation: Redox-neutral and traceless by N-N bond cleavage". supporting information. p. 12426 - 12429. Retrieved 2013/12/04.
• 2、 Buege, Axel,Locke, Christian,Koehler, Thomas,Nuhn, Peter. "Lipoxygenase Inhibitors, III: Synthesis of Tetrahydrobenzazepinone Phenylhydrazones". . p. 99 - 104. Retrieved 2007/10/02.