L-Mannono-1,4-lactone

Base Information

• Chemical Name: L-Mannono-1,4-lactone
• CAS No.: 22430-23-5
• Molecular Formula: C6H10 O6
• Molecular Weight: 178.142
• Hs Code.: 29322090
• Mol file: 22430-23-5.mol

Synonyms:Mannonicacid, g-lactone, L- (8CI);L-Mannolactone; L-Mannono-g-lactone

Chemical Property of L-Mannono-1,4-lactone

Chemical Property:

• Melting Point: 153-155 ºC
• Boiling Point: 467.9°Cat760mmHg
• PKA: 12.06±0.60(Predicted)
• Flash Point: 201.5°C
• PSA: 107.22000
• Density: 1.766g/cm³
• LogP: -3.01320
• Storage Temp.: −20°C
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated), Water (Sparingly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

L-Mannono-1,4-lactone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: L-mannono-1,4-lactone is a compound useful in organic synthesis.

Technology Process of L-Mannono-1,4-lactone

There total 13 articles about L-Mannono-1,4-lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

mannitol (69-65-8) → γ lactone of dl-mannonic acid (1128-23-0,1128-24-1,1198-69-2,1668-08-2,2426-46-2,2782-07-2,3158-30-3,3327-64-8,6322-07-2,10238-03-6,10366-82-2,18404-70-1,22430-23-5,23666-11-7,26301-79-1,29474-78-0,74464-44-1,78184-43-7,83602-36-2,119008-75-2,127997-10-8)

Guidance literature:

With 1-Phenylbut-1-en-3-one; rhodium hydrido (PEt₃)3 complex; In N,N-dimethyl-formamide; at 60 - 80 ℃;

DOI:10.1055/s-1998-1705

Reference yield: 60.0%

D-galactitol (608-66-2) → galactonic acid-4-lactone (1128-23-0,1128-24-1,1198-69-2,1668-08-2,2426-46-2,2782-07-2,3158-30-3,3327-64-8,6322-07-2,10238-03-6,10366-82-2,18404-70-1,22430-23-5,23666-11-7,26301-79-1,29474-78-0,74464-44-1,78184-43-7,83602-36-2,119008-75-2,127997-10-8)

Guidance literature:

With 1-Phenylbut-1-en-3-one; rhodium hydrido (PEt₃)3 complex; In N,N-dimethyl-formamide; Heating;

DOI:10.1055/s-1998-1705

Reference yield: 52.0%

D-galactose N,N'-diphenylformazan (19242-59-2,26754-43-8,26754-44-9,30694-33-8,30694-35-0,30694-36-1,58174-97-3) → D-galactono-1,4-lactone (1128-23-0,1128-24-1,1198-69-2,1668-08-2,2426-46-2,2782-07-2,3158-30-3,3327-64-8,6322-07-2,10238-03-6,10366-82-2,18404-70-1,22430-23-5,23666-11-7,26301-79-1,29474-78-0,74464-44-1,78184-43-7,83602-36-2,119008-75-2,127997-10-8)

Guidance literature:

With trifluoroacetic acid; In methanol; acetone; for 120h; Ambient temperature;

DOI:10.1016/0008-6215(94)90007-8

upstream raw materials:

hydrogen cyanide

L-arabinose

L-mannonic acid

L-(+)-arabinose

Downstream raw materials:

mannaric acid-1=>4;6=>3-dilactone

L-mannitol

2,3:5,6-di-O-cyclohexylidene-D-gulonic acid γ-lactone

(R)-3-Benzyloxy-5-((S)-1,2-dihydroxy-ethyl)-5H-furan-2-one

Refernces

• 1、 Zsoldos-Mady, Virag,Pinter, Istvan,Neszmelyi, Andras,Messmer, Andras,Perczel, Andras. "2-Acetamido-2-deoxyaldonolactones from sugar formazans". . p. 85 - 96. Retrieved 2007/10/02.
• 2、 Csuk, Rene,Glaenzer, Brigitte I.. "Deacetylation of α-acetoxy-furanurono-6,3-lactones by lipases and lyophilised yeast". . p. C9 - C11. Retrieved 2007/10/02.