Gluconic Acid

Base Information

• Chemical Name: Gluconic Acid
• CAS No.: 133-42-6
• Deprecated CAS: 723724-74-1,880385-91-1,887830-55-9,880385-91-1,887830-55-9
• Molecular Formula: C₆H₁₂O₇
• Molecular Weight: 196.157
• Hs Code.: 2918160000
• European Community (EC) Number: 208-401-4
• ICSC Number: 1738
• UNII: R4R8J0Q44B
• DSSTox Substance ID: DTXSID8027169,DTXSID8042000
• Nikkaji Number: J3.286G
• Wikipedia: Gluconic_acid
• Wikidata: Q407569
• NCI Thesaurus Code: C61777
• RXCUI: 2475956
• Metabolomics Workbench ID: 37337
• ChEMBL ID: CHEMBL464345
• Mol file: 133-42-6.mol

Synonyms:boron gluconate;D-gluconate;D-gluconic acid;dextronic acid;gluconate;gluconic acid;gluconic acid, (113)indium-labeled;gluconic acid, (14)C-labeled;gluconic acid, (159)dysprosium-labeled salt;gluconic acid, (99)technecium (5+) salt;gluconic acid, 1-(14)C-labeled;gluconic acid, 6-(14)C-labeled;gluconic acid, aluminum (3:1) salt;gluconic acid, ammonium salt;gluconic acid, calcium salt;gluconic acid, cesium(+3) salt;gluconic acid, cobalt (2:1) salt;gluconic acid, copper salt;gluconic acid, Fe(+2) salt, dihydrate;gluconic acid, lanthanum(+3) salt;gluconic acid, magnesium (2:1) salt;gluconic acid, manganese (2:1) salt;gluconic acid, monolithium salt;gluconic acid, monopotassium salt;gluconic acid, monosodium salt;gluconic acid, potassium salt;gluconic acid, sodium salt;gluconic acid, strontium (2:1) salt;gluconic acid, tin(+2) salt;gluconic acid, zinc salt;lithium gluconate;magnerot;magnesium gluconate;maltonic acid;manganese gluconate;pentahydroxycaproic acid;sodium gluconate;zinc gluconate

Chemical Property of Gluconic Acid

Chemical Property:

• Melting Point: 131oC
• Boiling Point: 673.6°Cat760mmHg
• PKA: 3.35±0.35(Predicted)
• Flash Point: 375.2°C
• PSA: 138.45000
• Density: 1.763g/cm³
• LogP: -3.49310
• XLogP3: -3.4
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 5
• Exact Mass: 196.05830272
• Heavy Atom Count: 13
• Complexity: 170

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Other Classes -> Organic Acids
• Canonical SMILES: C(C(C(C(C(C(=O)O)O)O)O)O)O
• Isomeric SMILES: C([C@H]([C@H]([C@@H]([C@H](C(=O)O)O)O)O)O)O
• Inhalation Risk: Evaporation at 20 °C is negligible; a nuisance-causing concentration of airborne particles can, however, be reached quickly when dispersed.

Technology Process of Gluconic Acid

There total 92 articles about Gluconic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.7%

D-Galactose (59-23-4) → D-galactonic acid (133-42-6,488-33-5,526-95-4,526-97-6,576-36-3,642-99-9,1114-17-6,3956-93-2,6906-37-2,7760-07-8,13382-27-9,20246-33-7,20246-35-9,20246-52-0,20246-53-1,21675-42-3,22430-69-9,24871-35-0,28223-42-9,28278-17-3,51547-37-6)

Guidance literature:

With potassium hydroxide; oxygen; gold on Al₂O₃; In water; at 40 ℃; for 2h; pH=9.0;

Reference yield: 87.1%

D-Galactose (10257-28-0) → D-galactonic acid (133-42-6,488-33-5,526-95-4,526-97-6,576-36-3,642-99-9,1114-17-6,3956-93-2,6906-37-2,7760-07-8,13382-27-9,20246-33-7,20246-35-9,20246-52-0,20246-53-1,21675-42-3,22430-69-9,24871-35-0,28223-42-9,28278-17-3,51547-37-6)

Guidance literature:

With oxygen; In water; at 39.84 ℃; for 2h; under 760.051 Torr; Schlenk technique;

DOI:10.1246/cl.160364

Reference yield: 2.0%

D-Galactose (59-23-4) → talonic acid (20246-35-9) + D-galactonic acid (133-42-6,488-33-5,526-95-4,526-97-6,576-36-3,642-99-9,1114-17-6,3956-93-2,6906-37-2,7760-07-8,13382-27-9,20246-33-7,20246-35-9,20246-52-0,20246-53-1,21675-42-3,22430-69-9,24871-35-0,28223-42-9,28278-17-3,51547-37-6)

Guidance literature:

With sodium anthraquinone-2-sulfonate; calcium chloride; In sodium hydroxide; at 50 ℃;

DOI:10.1016/0008-6215(84)85210-6

upstream raw materials:

L-gulose

D-Glucuronic acid

sodium D-lyxo-5-hexulosonate

sodium D-glucuronate

Downstream raw materials:

L-gluconic acid

gluconic acid

d-galactonic acid-semicarbazide

D-galactonic acid ; lead (II)-compound with lead (II)-oxide

Refernces

• 1、 Mao, Shuhong,Liu, Yanna,Hou, Yali,Ma, Xiaoyu,Yang, Juanjuan,Han, Haichao,Wu, Jianlin,Jia, Longgang,Qin, Huimin,Lu, Fuping. "Efficient production of sugar-derived aldonic acids by Pseudomonas fragi TCCC11892". . p. 39897 - 39901. Retrieved 2019/01/03.
• 2、 Rautiainen, Sari,Lehtinen, Petra,Chen, Jingjing,Vehkam?ki, Marko,Niemel?, Klaus,Leskel?, Markku,Repo, Timo. "Selective oxidation of uronic acids into aldaric acids over gold catalyst". . p. 19502 - 19507. Retrieved 2015/04/28.