2-Chloro-3-methylquinoline

Base Information

• Chemical Name: 2-Chloro-3-methylquinoline
• CAS No.: 57876-69-4
• Molecular Formula: C10H8 Cl N
• Molecular Weight: 177.633
• Hs Code.: 2933499090
• Mol file: 57876-69-4.mol

Synonyms:2-Chloro-3-methylquinoline;NSC 364026

Chemical Property of 2-Chloro-3-methylquinoline

Chemical Property:

• Appearance/Colour: white to beige crystalline needles or crystals
• Vapor Pressure: 0.005mmHg at 25°C
• Melting Point: 83-84 ºC
• Refractive Index: 1.6000 (estimate)
• Boiling Point: 286.6°Cat760mmHg
• PKA: 0.50±0.50(Predicted)
• Flash Point: 154.5°C
• PSA: 12.89000
• Density: 1.225g/cm³
• LogP: 3.19660
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility.: Insoluble in water.

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-3-methylquinoline ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 24/25-39-26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Chloro-3-methylquinoline is used as organic chemical synthesis intermediate.

Technology Process of 2-Chloro-3-methylquinoline

There total 20 articles about 2-Chloro-3-methylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-phenyl-1H-quinolin-2-one (38035-81-3) → 2-chloro-3-methyl-quinoline (57876-69-4)

Guidance literature:

With trichlorophosphate; for 2.5h; Heating;

DOI:10.1248/cpb.35.2819

Reference yield: 82.0%

3-methylcarbostyril (2721-59-7) → 2-chloro-3-methyl-quinoline (57876-69-4)

Guidance literature:

With trichlorophosphate; at 0 - 90 ℃; for 3h;

DOI:10.1021/acs.jmedchem.5b00772

Reference yield: 62.0%

N-(phenyl)-2-methylacetamide (620-71-3) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-chloro-3-methyl-quinoline (57876-69-4)

Guidance literature:

With trichlorophosphate; at 75 ℃; for 5h;

DOI:10.1039/P19810001537

upstream raw materials:

3-methylquinoline N-oxide

3-methyl-3,4-dihydroquinolin-2(1H)-one

3-phenyl-1H-quinolin-2-one

N-(phenyl)-2-methylacetamide

Downstream raw materials:

3-methylquinoline

3-Methylcarbostyril

2-amino-3-methylquinoline

Refernces

• 1、 Sugimoto, Osamu,Iwasaki, Hyuma,Tanji, Ken-Ichi. "Development of a facile and inexpensive route for the preparation of α-halobenzopyridines from α-unsubstituted benzopyridines". . p. 1445 - 1454. Retrieved 2015/07/15.
• 2、 -. "HETEROCYCLES FOR USE AS INHIBITORS OF LEUKOTRIENES". . . Retrieved 2008/06/13.