38035-81-3

Basic information

• Product Name: 3-phenylquinolin-2(1H)-one
• Synonyms: 3-phenyl-2-quinolone
• CAS NO: 38035-81-3
• Molecular Formula: C₁₅H₁₁NO
• Molecular Weight: 221.2539
• Mol File: 38035-81-3.mol
• Article Data: 44

Chemical Properties

• Boiling Point: 445.4°C at 760 mmHg
• Flash Point: 266.6°C
• Density: 1.2g/cm³
• Vapor Pressure: 3.96E-08mmHg at 25°C
• Refractive Index: 1.634
• CAS DataBase Reference: 3-phenylquinolin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenylquinolin-2(1H)-one(38035-81-3)
• EPA Substance Registry System: 3-phenylquinolin-2(1H)-one(38035-81-3)

Safety Data

• Hazardous Substances Data: 38035-81-3(Hazardous Substances Data)

Upstream product

• 103-82-2 phenylacetic acid 
• 529-23-7 o-aminobenzaldehyde 
• 1555-80-2 phenylacetic anhydride 
• 220466-11-5 1-isocyanato-2-(2-phenylethynyl)benzene 
• 868739-64-4 N-(2-formylphenyl)-2-phenylacetamide 
• 59-31-4 2-quinolone 
• 98-80-6 phenylboronic acid 
• 13141-39-4 N-<2-(2-Phenylethynyl)phenyl>methanamide 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 247222-84-0 2-(2-phenylethynyl)phenyl isocyanide 
• 6462-50-6 sodium 4-methoxybenzenesulfinate 
• 14752-66-0 sodium p-chlorobenzenesulphinate 
• 34176-08-4 sodium 4-bromobenzenesulfinate 
• 15959-31-6 sodium 4-nitrobenzenesulfinate 

Downstream Products

• 2859-30-5 2-chloro-3-phenyl-quinoline 
• 1254212-16-2 3-phenyl-2-(3-phenylquinolin-2-yloxy)quinoline 
• 78597-76-9 5-(1,2-Dihydro-2-oxo-3-phenylquinol-1-yl)-valeric acid ethyl ester 
• 78587-98-1 1,2-dihydro-2-oxo-3-phenylquinol-1-yl-acetic acid ethyl ester 
• 113093-00-8 2-[4-(3-Phenyl-quinolin-2-yl)-piperazin-1-yl]-ethanol 
• 113092-99-2 2-(4-Ethyl-piperazin-1-yl)-3-phenyl-quinoline 
• 113092-98-1 2-(4-Methyl-piperazin-1-yl)-3-phenyl-quinoline 
• 113092-97-0 3-Phenyl-2-piperazin-1-yl-quinoline 
• 841303-92-2 4-(3-phenyl-quinolin-2-yl)-benzaldehyde 
• 841303-91-1 trifluoro-methanesulfonic acid 3-phenyl-quinolin-2-yl ester 
• 57876-69-4 2-chloro-3-methyl-quinoline 

Relevant articles and documents

Solvent-Dependent Cyclization of 2-Alkynylanilines and ClCF2COONa for the Divergent Assembly of N-(Quinolin-2-yl)amides and Quinolin-2(1 H)-ones

Herein, we present an expedient Cu-catalyzed [5 + 1] cyclization of 2-alkynylanilines and ClCF2COONa to divergent construction of N-(quinolin-2-yl)amides and quinolin-2(1H)-ones by regulating the reaction solvents. Notably, nitrile acts as a solvent and performs the Ritter reactions. ClCF2COONa is used as a C1 synthon in this transformation, which also represents the first example for utilization of ClCF2COONa as an efficient desiliconization reagent. The current protocol involves in situ generation of isocyanide, copper-activated alkyne, Ritter reaction and protonation.

Palladium-catalyzed carbonylative synthesis of 3-arylquinolin-2(1H)-ones from benzyl chlorides and o-nitrobenzaldehydes

A palladium-catalyzed carbonylative cyclization of benzyl chlorides with o-nitrobenzaldehydes has been developed for the synthesis of 3-arylquinolin-2(1H)-ones. Mo(CO)6 played a dual role as both a CO surrogate and a reductant in this carbonylative transformation.

Regio- And Stereoselective Synthesis of Diverse 3,4-Dihydro-2-quinolones through Catalytic Hydrative Cyclization of Imine- And Carbonyl-Ynamides with Water

Transition-metal-catalyzed alkyne hydration reaction has attracted considerable interest in the past decades because this approach would lead to the facile and efficient formation of synthetically useful carbonyls. However, transition-metal-catalyzed alky