2-Phenylethylamine hydrochloride

Base Information

• Chemical Name: 2-Phenylethylamine hydrochloride
• CAS No.: 156-28-5
• Molecular Formula: C8H12ClN
• Molecular Weight: 157.643
• Hs Code.: 2921499090
• Mol file: 156-28-5.mol

Synonyms:Benzeneethanamine,hydrochloride (9CI);Phenethylamine, hydrochloride (8CI);2-Phenethylaminehydrochloride;2-Phenethylammonium chloride;Benzeneethanamine,hydrochloride (1:1);2-Phenylethylammonium chloride;Phenethylammonium chloride;b-Phenethylamine hydrochloride;b-Phenylethylamine hydrochloride;

Chemical Property of 2-Phenylethylamine hydrochloride

Chemical Property:

• Vapor Pressure: 0.398mmHg at 25°C
• Melting Point: 220-222 °C(lit.)
• Boiling Point: 196.5 °C at 760 mmHg
• Flash Point: 90.6 °C
• PSA: 26.02000
• LogP: 2.69010
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 157.0658271
• Heavy Atom Count: 10
• Complexity: 65

Purity/Quality:

99.00% ^*data from raw suppliers

2-Phenylethylamine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xn,Xi,C
• Statements: 22-36/37/38-34
• Safety Statements: 26-36-45-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CC[NH3+].[Cl-]
• Description: 2-Phenethylamine is a natural monoamine alkaloid that acts as neuromodulator in the central nervous system. It stimulates the release of norepinephrine and dopamine and is metabolized by monoamine oxidases as well as other enzymes. This product is intended for forensic and research applications.
• Uses: 2-Phenylethylamine hydrochloride is the hydrochloride salt form of 2-Phenylethylamine, which is an biogenic aromatic amine acting as a monoaminergic neuromodulator or a neurotransmitter in the human central nervous system. It is used to CNS stimulant.

Technology Process of 2-Phenylethylamine hydrochloride

There total 44 articles about 2-Phenylethylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

phenethyl azide (6926-44-9) → 2-phenylethylamine hydrochloride (156-28-5)

Guidance literature:

phenethyl azide; With triphenylphosphine; at 110 ℃; for 20h; Green chemistry;

With hydrogenchloride; In 1,4-dioxane; diethyl ether; Green chemistry;

DOI:10.1039/c8gc02136h

Reference yield: 90.0%

phenethylamine (64-04-0) → 2-phenylethylamine hydrochloride (156-28-5)

Guidance literature:

With hydrogenchloride; In methanol;

DOI:10.1039/c7cy01577a

Reference yield: 83.0%

2-Phenylnitroethane (6125-24-2) → 2-phenylethylamine hydrochloride (156-28-5)

Guidance literature:

2-Phenylnitroethane; With C₃₆H₅₆Cl₃CrN₂O; magnesium; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In tetrahydrofuran; at 60 ℃; for 24h; Inert atmosphere; Schlenk technique;

With hydrogenchloride; In tetrahydrofuran; water; ethyl acetate; at 20 ℃;

DOI:10.1021/jacs.0c12318

upstream raw materials:

methanol

Nα-diphenylphosphinyl-2-phenylethylamine

N-(2-phenylethyl)-P,P-dimethylphosphinamide

N-(2-phenylethyl)-P,P-diethylphosphinamide

Downstream raw materials:

1,3,5-triphenylethyl-1,3,5-triazacyclohexane

5,5'-diphenethyl-1,1'-hexanediyl-bis-biguanide

phenformin

2-nitro-N-(2-phenylethyl)benzamide

Refernces

• 1、 Gong, Mingliang,Guo, Chenjun,Luo, Yunjie,Xie, Hongzhen,Zhang, Fangcao. "Hydroborative reduction of amides to amines mediated by La(CH2C6H4NMe2-: O)3". . p. 779 - 791. Retrieved 2022/01/22.
• 2、 Guo, Chenjun,Zhang, Fangcao,Yu, Chong,Luo, Yunjie. "Reduction of Amides to Amines with Pinacolborane Catalyzed by Heterogeneous Lanthanum Catalyst La(CH2C6H4NMe2- o)3@SBA-15". . p. 13122 - 13135. Retrieved 2021/08/31.