6926-44-9

Basic information

• Product Name: Benzene, (2-azidoethyl)-
• Synonyms: Benzene, (2-azidoethyl)-
• CAS NO: 6926-44-9
• Molecular Formula: C₈H₉N₃
• Molecular Weight: 0
• Mol File: 6926-44-9.mol
• Article Data: 104

Chemical Properties

• Boiling Point: 68 °C(Press: 0.5 Torr)
• Appearance: /
• CAS DataBase Reference: Benzene, (2-azidoethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, (2-azidoethyl)-(6926-44-9)
• EPA Substance Registry System: Benzene, (2-azidoethyl)-(6926-44-9)

Safety Data

• Hazardous Substances Data: 6926-44-9(Hazardous Substances Data)

Usage

Description

Benzene, (2-azidoethyl)-, also known as (2-azidoethyl)benzene, is an organic compound with a benzene ring and an azidoethyl group attached to it. Benzene, (2-azidoethyl)is characterized by its reactivity and potential applications in various chemical reactions and industries.

Uses

Used in Chemical Synthesis:
Benzene, (2-azidoethyl)is used as a reactant in the preparation of disubstituted triazoles. The application reason is its ability to participate in ruthenium-catalyzed cycloaddition reactions with terminal alkynes and azides, leading to the formation of disubstituted triazoles, which are important compounds in various fields such as pharmaceuticals, materials science, and chemical research.

InChI:InChI=1/C8H9N3/c9-11-10-7-6-8-4-2-1-3-5-8/h1-5H,6-7H2

Upstream product

• 103-63-9 1-phenyl-2-bromoethane 
• 1927-61-3 2-(2-phenylethoxy)tetrahydro-2H-pyran 
• 1246367-30-5 benzotriazol-1-yl-sulfonyl azide 
• 64-04-0 phenethylamine 
• 55419-66-4 trifluoroacetic acid 2-phenylethyl ester 
• 4455-09-8 2-phenylethyl tosylate 
• 60-12-8 2-phenylethanol 
• 17376-04-4 2-phenethyl iodide 
• 122-78-1 phenylacetaldehyde 
• 622-24-2 2-phenylethyl chloride 
• 1266134-54-6 2-azido-1,3-dimethyl-4,5-dihydro-1H-imidazol-3-ium hexafluorophosphate (V) 
• 20020-27-3 2-phenylethyl mesylate 

Downstream Products

• 65259-56-5 phenylacetaldehyde dimethylhydrazone 
• 38427-90-6 N-(t-butoxycarbonyl)phenethylamine 
• 5460-60-6 N-phenethyl-2-phenylacetamide 
• 251350-20-6 N-phenethyl-heptanamide 
• 33542-82-4 N-phenethyl-N-(1'-phenylethyl)formamide 
• 41431-75-8 N-phenethyl-2-phenylpropanamide 
• 53050-54-7 phenethylamine; toluene-4-sulfonate 
• 1013656-63-7 C₂₈H₃₂N₄O₃S₂ 

Relevant articles and documents

Controlling the selectivity of C-H activation in pyridinium triazolylidene iridium complexes: Mechanistic details and influence of remote substituents

Iridium complexes containing a triazolylidene ligand with an appended methylpyridinium site undergo either aromatic C(sp2)-H bond activation or exocyclic C(sp3)-H bond activation of the N-bound methyl group. The selectivity of these

Two-Step Protocol for Iodotrimethylsilane-Mediated Deoxy-Functionalization of Alcohols

We have developed a two-step protocol for iodotrimethylsilane-mediated deoxy-functionalization of primary and secondary alcohols to afford products containing a C?N, C?S, or C?O bond. In the first step the alcohol undergoes iodination with iodotrimethylsilane, and in the second, the iodine atom is replaced by a N, S, or O nucleophile. Compared with traditional Mitsunobu reaction, non-acidic pre-nucleophiles can be used, and the reaction proceeds with retention of configuration. This operationally simple, highly efficient protocol can be used for some natural products and small-molecule drugs containing hydroxy-group.

Synthesis, antimicrobial evaluation, and in silico studies of quinoline—1H-1,2,3-triazole molecular hybrids

Abstract: Antimicrobial resistance has become a significant threat to global public health, thus precipitating an exigent need for new drugs with improved therapeutic efficacy. In this regard, molecular hybridization is deemed as a viable strategy to afford multi-target-based drug candidates. Herein, we report a library of quinoline—1H-1,2,3-triazole molecular hybrids synthesized via copper(I)-catalyzed azide-alkyne [3 + 2] dipolar cycloaddition reaction (CuAAC). Antimicrobial evaluation identified compound 16 as the most active hybrid in the library with a broad-spectrum antibacterial activity at an MIC80 value of 75.39?μM against methicillin-resistant S. aureus, E. coli, A. baumannii, and multidrug-resistant K. pneumoniae. The compound also showed interesting antifungal profile against C. albicans and C. neoformans at an MIC80 value of 37.69 and 2.36?μM, respectively, superior to fluconazole. In vitro toxicity profiling revealed non-hemolytic activity against human red blood cells (hRBC) but partial cytotoxicity to human embryonic kidney cells (HEK293). Additionally, in silico studies predicted excellent drug-like properties and the importance of triazole ring in stabilizing the complexation with target proteins. Overall, these results present compound 16 as a promising scaffold on which other molecules can be modeled to deliver new antimicrobial agents with improved potency. Graphic abstract: [Figure not available: see fulltext.].

ISOINDOLINE COMPOUND, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION OF ISOINDOLINE COMPOUND

The present invention relates to an isoindoline compound as represented by general formula (I) and used as a CRBN regulator, and a preparation method, a pharmaceutical composition, and an application of the isoindoline compound. Specifically, a class of polysubstituted isoindoline compound provided in the present invention, as a class of CRL4CRBN E3 ubiquitin ligase regulator having a novel structure, has good anti-tumor activity and immunoregulatory activity, and can be used for preparing drugs for treating diseases associated with a CRL4CRBN E3 ubiquitin ligase.