Diglyme

Base Information Edit

Chemical Name:Diglyme
CAS No.:111-96-6
Deprecated CAS:142939-39-7,54631-70-8,70992-86-8,54631-70-8,70992-86-8
Molecular Formula:C6H14O3
Molecular Weight:134.175
Hs Code.:29091990
European Community (EC) Number:203-924-4
ICSC Number:1357
NSC Number:59726
UN Number:2252,1993
UNII:M4BH3X0MVZ
DSSTox Substance ID:DTXSID1024621
Nikkaji Number:J5.118G
Wikipedia:Diglyme
Wikidata:Q865952
Metabolomics Workbench ID:56700
ChEMBL ID:CHEMBL1234162
Mol file:111-96-6.mol

Synonyms:bis(2-methoxyethyl)ether;DGDME;diethylene glycol dimethyl ether;diglyme

Suppliers and Price of Diglyme

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
DiethyleneGlycolDimethylEther(Diglyme)
1g
$ 135.00

TCI Chemical
Diethylene Glycol Dimethyl Ether >99.0%(GC)
25mL
$ 15.00

TCI Chemical
Diethylene Glycol Dimethyl Ether >99.0%(GC)
500mL
$ 43.00

Sigma-Aldrich
Diethylene glycol dimethyl ether analytical standard
1 mL
$ 25.10

Sigma-Aldrich
Diethylene glycol dimethyl ether analytical standard
1ml-f
$ 24.30

Sigma-Aldrich
Diethylene glycol dimethyl ether (stabilised) for synthesis. CAS 111-96-6, pH (H O, 20 °C) neutral., (stabilised) for synthesis
8029340250
$ 37.90

Sigma-Aldrich
Diethylene glycol dimethyl ether (stabilised) for synthesis
250 mL
$ 36.26

Sigma-Aldrich
Diethylene glycol dimethyl ether (stabilised) for synthesis. CAS 111-96-6, pH (H O, 20 °C) neutral., (stabilised) for synthesis
8029341000
$ 127.00

Sigma-Aldrich
Diethylene glycol dimethyl ether (stabilised) for synthesis
1 L
$ 121.17

Sigma-Aldrich
Diethylene glycol dimethyl ether ReagentPlus , 99%
500ml
$ 106.00

Total 173 raw suppliers

Chemical Property of Diglyme Edit

Chemical Property:

Appearance/Colour:clear liquid
Vapor Pressure:3 mm Hg ( 20 °C)
Melting Point:-64 ºC
Refractive Index:1.4097
Boiling Point:159.8 ºC at 760 mmHg
Flash Point:70 ºC
PSA：27.69000
Density:0.914 g/cm³
LogP:0.29580
Storage Temp.:Flammables area
Sensitive.:Hygroscopic
Water Solubility.:Miscible
XLogP3:-0.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:134.094294304
Heavy Atom Count:9
Complexity:41.6
Transport DOT Label:Flammable Liquid

Purity/Quality:

99% ^*data from raw suppliers

DiethyleneGlycolDimethylEther(Diglyme) ^*data from reagent suppliers

Safty Information:

Pictogram(s): T
Hazard Codes:T
Statements: 60-61-10-19
Safety Statements: 53-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Chemical Classes:Solvents -> Glycol Ethers (Glymes)
Canonical SMILES:COCCOCCOC
Inhalation Risk:A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20 °C.
Effects of Short Term Exposure:The substance is mildly irritating to the eyes, skin and respiratory tract.
Effects of Long Term Exposure:Animal tests show that this substance possibly causes toxicity to human reproduction or development.
Description Bis (2-methoxyethyl) ether, also known as diglyme, is a linear aliphatic diether widely used as a solvent and present as a clear liquid at room temperature with a mild ether odor. The compound is notknown to occur in nature. It is synthesized from ethylene oxide and methanol in the presence of either acidic or basic catalysts. The reaction is based on the classic Williamson ether synthesis. It can also be produced from diethylene glycol and dimethyl sulfate. In June 2012, ECHA proposed addition of diglyme to the REACH very high concern list.
Uses Solvent; it is used as reaction medium for Grignard and similar synthesis. Solvent; reaction medium for Grignard and similar syntheses. Bis (2-methoxyethyl) ether, due to being chemically inert and possessing excellent solvent properties, is mainly used as a solvent and an anhydrous reaction medium for organometallic synthesis. It is also used as a solubilizer. Diethylene glycol dimethyl ether is used as a solvent in organic reactions due to its stability towards higher pH and its high boiling point. It is particularly involved in reactions utilizing organometallic reagents such as Grignard reactions and metal hydride reductions. It is also a solvent for hydroboration reactions with diborane.

Technology Process of Diglyme

There total 31 articles about Diglyme which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%