(1R)((5R)-5-vinylquinuclidin-2-yl)-4-quinolylmethan-1-ol

Base Information Edit

Chemical Name:(1R)((5R)-5-vinylquinuclidin-2-yl)-4-quinolylmethan-1-ol
CAS No.:118-10-5
Deprecated CAS:1236363-47-5,185122-83-2,201406-15-7,24831-03-6,887770-70-9,896440-46-3,898337-50-3,898814-05-6,900786-85-8,909881-46-5,910892-13-6
Molecular Formula:C19H22N2O
Molecular Weight:294.396
Hs Code.:29339900
European Community (EC) Number:204-234-6
Nikkaji Number:J1.503.306A
Wikipedia:Cinchonine
Mol file:118-10-5.mol

Synonyms:MLS006011995;NP89;SCHEMBL18950292;118-10-5;AKOS030504193;SMR004703548;(1R)((5R)-5-vinylquinuclidin-2-yl)-4-quinolylmethan-1-ol

Suppliers and Price of (1R)((5R)-5-vinylquinuclidin-2-yl)-4-quinolylmethan-1-ol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TCI Chemical
Cinchonine >98.0%(T)
200g
$ 330.00

TCI Chemical
Cinchonine >98.0%(T)
25g
$ 64.00

Sigma-Aldrich
(+)-Cinchonine for resolution of racemates for synthesis. CAS 118-10-5, pH 9.0 (0.25 g/l, H O, 20 °C) (as aqueous solution)., for resolution of racemates for synthesis
8025060025
$ 61.50

Sigma-Aldrich
(+)-Cinchonine for resolution of racemates for synthesis
25 g
$ 58.92

Sigma-Aldrich
Cinchonine crystallized, ≥98.0% (NT)
100g
$ 138.00

Sigma-Aldrich
(+)-Cinchonine 85%
100g
$ 130.00

Sigma-Aldrich
(+)-Cinchonine 85%
25g
$ 46.40

Sigma-Aldrich
Cinchonine crystallized, ≥98.0% (NT)
25g
$ 44.80

Sigma-Aldrich
(+)-Cinchonine for resolution of racemates for synthesis. CAS 118-10-5, pH 9.0 (0.25 g/l, H O, 20 °C) (as aqueous solution)., for resolution of racemates for synthesis
8025060100
$ 183.00

Sigma-Aldrich
(+)-Cinchonine for resolution of racemates for synthesis
100 g
$ 174.82

Total 138 raw suppliers

Chemical Property of (1R)((5R)-5-vinylquinuclidin-2-yl)-4-quinolylmethan-1-ol Edit

Chemical Property:

Appearance/Colour:white to light yellow crystal powder
Vapor Pressure:0mmHg at 25°C
Melting Point:256-266 °C
Refractive Index:223 ° (C=0.5, EtOH)
Boiling Point:464.5 °C at 760 mmHg
PKA:5.85, 9.92(at 25℃)
Flash Point:234.7 °C
PSA：36.36000
Density:1.2 g/cm³
LogP:3.10250
Storage Temp.:Store below +30°C.
Sensitive.:Light Sensitive
Solubility.:0.25g/l
Water Solubility.:Insoluble
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:294.173213330
Heavy Atom Count:22
Complexity:412

Purity/Quality:

99% ^*data from raw suppliers

Cinchonine >98.0%(T) ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 20/22-20/21/22
Safety Statements: 26-36-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C=CC1CN2CCC1CC2C(C3=CC=NC4=CC=CC=C34)O
Isomeric SMILES:C=C[C@H]1CN2CCC1CC2[C@@H](C3=CC=NC4=CC=CC=C34)O
Description Cinchonine is a cinchona alkaloid generally found in the bark of Cinchona officinalis plants. It is a pseudoenantiomer that is commonly employed in malaria therapy. Cinchonine is also used as an organocatalyst in many asymmetric reactions. It is a stereoisomer and pseudo-enantiomer of cinchonidine. It is structurally similar to quinine, an antimalarial drug.
Uses cardiotonic Stereomeric with Cinchonidine (C441925). Antimalarial. Cinchonine occurs in most varieties of cinchonabark (Cinchona micrantha and Rubiaceae).It is used as an antimalarial agent.

Technology Process of (1R)((5R)-5-vinylquinuclidin-2-yl)-4-quinolylmethan-1-ol

There total 53 articles about (1R)((5R)-5-vinylquinuclidin-2-yl)-4-quinolylmethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%