2-AMino-N-(2,2,2-trifluoroethyl)acetaMide hydrochloride

Base Information

• Chemical Name: 2-AMino-N-(2,2,2-trifluoroethyl)acetaMide hydrochloride
• CAS No.: 1171331-39-7
• Molecular Formula: C₄H₇F₃N₂O*ClH
• Molecular Weight: 192.569
• Hs Code.: 2922498590
• Mol file: 1171331-39-7.mol

Synonyms:1-oxo-1-N-(2,2,2-trifluoroethyl)-1,2-diaminoethane hydrochloride

Chemical Property of 2-AMino-N-(2,2,2-trifluoroethyl)acetaMide hydrochloride

Chemical Property:

• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99.9% ^*data from raw suppliers

2-Amino-N-(2,2,2-trifluoroethyl)acetamidehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Reactant in the synthesis of isoxazoline indolizine amides.

Technology Process of 2-AMino-N-(2,2,2-trifluoroethyl)acetaMide hydrochloride

There total 5 articles about 2-AMino-N-(2,2,2-trifluoroethyl)acetaMide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-N-(tert-butoxycarbonyl)-1-oxo-1-N-(2,2,2-trifluoroethyl)-1,2-diaminoethane (1231755-15-9) → 1-oxo-1-N-(2,2,2-trifluoroethyl)-1,2-diaminoethane hydrochloride (1171331-39-7)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 12h;

Reference yield: 85.96%

2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-N-(2,2,2-trifluoroethyl)acetamide → 1-oxo-1-N-(2,2,2-trifluoroethyl)-1,2-diaminoethane hydrochloride (1171331-39-7)

Guidance literature:

2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-N-(2,2,2-trifluoroethyl)acetamide; With hydrazine hydrate; In isopropyl alcohol; at 75 - 80 ℃; for 6h;

With hydrogenchloride; In isopropyl alcohol; for 2h;

Reference yield:

2-[bis(phenylmethyl)amino]-N-(2,2,2-trifluoroethyl)acetamide (1371632-80-2) → 1-oxo-1-N-(2,2,2-trifluoroethyl)-1,2-diaminoethane hydrochloride (1171331-39-7)

Guidance literature:

2-[bis(phenylmethyl)amino]-N-(2,2,2-trifluoroethyl)acetamide; With hydrogen; 5%-palladium/activated carbon; In methanol; at 70 ℃; under 5171.62 Torr; Inert atmosphere;

With hydrogenchloride; In methanol; at 20 ℃; Product distribution / selectivity;

upstream raw materials:

2-N-(tert-butoxycarbonyl)-1-oxo-1-N-(2,2,2-trifluoroethyl)-1,2-diaminoethane

2-[bis(phenylmethyl)amino]-N-(2,2,2-trifluoroethyl)acetamide

phenylmethyl N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]carbamate

2-ammonia-N-(2,2,2-trifluoroethyl)acetamide

Downstream raw materials:

2-({2-chloro-4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-N-hydroxy-benzimidoyl}-amino)-N-(2,2,2-trifluoro-ethyl)-acetamide

3-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-oxo-2-(2,2,2-trifluoroethylamino)ethyl)-5,6-dihydro-4H-cyclopenta[c]thiophene-1-carboxamide

(Z)-2-Bromo-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzamide

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]benzamide

Refernces

• 1、 -. "MOLECULES HAVEING PESTICIDAL UTILIY AND INTERMEDIATES, COMPOSITIONS AND PROCESSES RELATED THERETO". Paragraph 3191-3192. . Retrieved 2018/04/20.
• 2、 -. "2-amino-N-(2, 2, 2-trifluoroethyl) or its salt aminoacetamide compd.". Paragraph 0068. . Retrieved 2017/01/02.