2-amino-N-(2,2,2-trifluoroethyl)acetamide

Base Information

• Chemical Name: 2-amino-N-(2,2,2-trifluoroethyl)acetamide
• CAS No.: 359821-38-8
• Molecular Formula: C₄H₇F₃N₂O
• Molecular Weight: 156.108
• Hs Code.: 2922498590
• Mol file: 359821-38-8.mol

Synonyms:2-amino-N-(2,2,2-trifluoroethyl)acetamide

Chemical Property of 2-amino-N-(2,2,2-trifluoroethyl)acetamide

Chemical Property:

• Boiling Point: 227.5±40.0 °C(Predicted)
• PKA: 12.87±0.46(Predicted)
• PSA: 55.12000
• Density: 1.294±0.06 g/cm3(Predicted)
• LogP: 0.71480
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-N-(2,2,2-trifluoroethyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-amino-N-(2,2,2-trifluoroethyl)acetamide

There total 2 articles about 2-amino-N-(2,2,2-trifluoroethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-chloro-N-(2,2,2-trifluoroethyl)acetamide (170655-44-4) → 2-ammonia-N-(2,2,2-trifluoroethyl)acetamide (359821-38-8)

Guidance literature:

2-chloro-N-(2,2,2-trifluoroethyl)acetamide; With ammonium hydroxide; In water; at 60 ℃; for 1h; under 3000.3 - 3750.38 Torr; Autoclave;

In water;

Reference yield: 88.6%

2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-N-(2,2,2-trifluoroethyl)acetamide → 2-ammonia-N-(2,2,2-trifluoroethyl)acetamide (359821-38-8)

Guidance literature:

With hydrazine hydrate; In ethanol; at 40 ℃; for 8h; Concentration; Solvent; Temperature;

Reference yield: 88.6%

4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-methyl-benzonitrile (930110-37-5) + 2-ammonia-N-(2,2,2-trifluoroethyl)acetamide (359821-38-8) → A1443 (864731-61-3)

Guidance literature:

With hydroxylamine hydrochloride; zinc trifluoromethanesulfonate; In 5,5-dimethyl-1,3-cyclohexadiene; water; at 110 ℃; for 8h; Sealed tube;

upstream raw materials:

2-chloro-N-(2,2,2-trifluoroethyl)acetamide

Downstream raw materials:

(E)-2-Chloro-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzamide

C₂₄H₁₆Cl₂F₆N₄O₃

1-oxo-1-N-(2,2,2-trifluoroethyl)-1,2-diaminoethane hydrochloride

A₁₄₄₃

Refernces

• 1、 -. "2-amino-N-(2, 2, 2-trifluoroethyl) or its salt aminoacetamide compd.". Paragraph 0059. . Retrieved 2017/01/02.