TERT-BUTYL 4-(1-AMINOETHYL)PIPERIDINE-1-CARBOXYLATE

Base Information

• Chemical Name: TERT-BUTYL 4-(1-AMINOETHYL)PIPERIDINE-1-CARBOXYLATE
• CAS No.: 455267-29-5
• Molecular Formula: C12H24N2O2
• Molecular Weight: 228.335
• Hs Code.: 2933399090
• Mol file: 455267-29-5.mol

Synonyms:TERT-BUTYL 4-(1-AMINOETHYL)PIPERIDINE-1-CARBOXYLATE;1-Boc-4-(1-aMinoethyl)-piperidine;4-(1-Amino-ethyl)-piperidine-1-carboxylic acid tert-butyl ester;4-(1-Aminoethyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester;(S)-tert-butyl 4-(1-aminoethyl)piperidine-1-carboxylate;4-(1-aminoethyl)-1-Piperidine carbocylic acid 1,1-dimethylethyl ester;1-Piperidinecarboxylicacid,4-(1-aminoethyl)-,1,1-dimethylethylester

Chemical Property of TERT-BUTYL 4-(1-AMINOETHYL)PIPERIDINE-1-CARBOXYLATE

Chemical Property:

• PSA: 55.56000
• LogP: 2.61890
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

95-99% ^*data from raw suppliers

tert-Butyl4-(1-Aminoethyl)piperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of TERT-BUTYL 4-(1-AMINOETHYL)PIPERIDINE-1-CARBOXYLATE

There total 11 articles about TERT-BUTYL 4-(1-AMINOETHYL)PIPERIDINE-1-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-acetyl-1-(t-butoxycarbonyl)piperidine (206989-61-9) → 4-(1-amino-ethyl)-piperidine-1-carboxylic acid tert-butyl ester (455267-29-5)

Guidance literature:

4-acetyl-1-(t-butoxycarbonyl)piperidine; With ammonium acetate; acetic acid; In methanol; at 25 ℃; for 2h;

With sodium cyanoborohydride; In methanol; at 25 ℃; for 16h;

Reference yield:

tert-butyl 4-((S)-1-(1,1-dimethylethylsulfinamido)ethyl)piperidine-1-carboxylate (1450658-46-4) → 4-(1-amino-ethyl)-piperidine-1-carboxylic acid tert-butyl ester (455267-29-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 1h;

Reference yield:

4-(1-hydroxyimino-ethyl)-piperidine-1-carboxylic acid tert-butyl ester + nickel (7440-02-0) → 4-(1-amino-ethyl)-piperidine-1-carboxylic acid tert-butyl ester (455267-29-5)

Guidance literature:

With ammonia; hydrogen; In ethanol; chloroform;

upstream raw materials:

nickel

4-acetyl-1-(t-butoxycarbonyl)piperidine

di-tert-butyl dicarbonate

1-(4-piperidinyl)ethanone

Downstream raw materials:

C₈H₈O₃*C₁₂H₂₄N₂O₂

C₈H₈O₃*C₁₂H₂₄N₂O₂

tert-butyl 4-(1-(3-(2-bromophenyl)-4-methoxy-4-oxobut-2-en-2-ylamino)ethyl)piperidine-1-carboxylate

tert-butyl 4-[(1R)-1-aminoethyl]piperidine-1-carboxylate

Refernces

• 1、 -. "SMYD INHIBITORS". Paragraph 0614; 0623-0625. . Retrieved 2017/07/18.
• 2、 -. "MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF". Paragraph 0072. . Retrieved 2014/08/20.