(Bromodifluoromethyl)trimethylsilane

Base Information

• Chemical Name: (Bromodifluoromethyl)trimethylsilane
• CAS No.: 115262-01-6
• Molecular Formula: C4H9BrF2Si
• Molecular Weight: 203.102
• Hs Code.: 29319090
• European Community (EC) Number: 806-938-4
• Nikkaji Number: J823.673I
• Mol file: 115262-01-6.mol

Synonyms:(bromodifluoromethyl)trimethylsilane

Chemical Property of (Bromodifluoromethyl)trimethylsilane

Chemical Property:

• Refractive Index: n/D1.407
• Boiling Point: 108°C(lit.)
• Flash Point: 46℃
• PSA: 0.00000
• Density: 1.306
• LogP: 3.27140
• Storage Temp.: -20°C
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 201.96250
• Heavy Atom Count: 8
• Complexity: 86.5

Purity/Quality:

98%,99%, ^*data from raw suppliers

Trimethyl(bromodifluoromethyl)silane ^*data from reagent suppliers

Safty Information:

• Statements: 11
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[Si](C)(C)C(F)(F)Br
• Uses: Novel difluorocarbene source for the efficient difluoromethylenation of alkenes/alkynes and difluoromethylation of O-, S-, and N-nucleophiles. Trimethyl(bromodifluoromethyl)silane can be used as neuroactive steroids. As reported by Hu and co-workers, (Bromodifluoromethyl)trimethylsilane is a highly useful reagent for the formation of difluoromethene-containing 3-membered rings and can also difluoromethylate heteroatoms with the assistance of alkaline bases, most effectively KOH.

Technology Process of (Bromodifluoromethyl)trimethylsilane

There total 2 articles about (Bromodifluoromethyl)trimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloro-trimethyl-silane (75-77-4) + halon-1211 (353-59-3) → bromodifluoromethane (1511-62-2) + Chlorodifluoromethane (75-45-6) + trimethylsilyl fluoride (420-56-4) + [bromo(difluoro)methyl]-trimethyl-silane (115262-01-6) + [chloro(difluoro)methyl]trimethylsilane (115262-00-5)

Guidance literature:

With 1-methyl-pyrrolidin-2-one; aluminium; Mechanism; Product distribution; Ambient temperature; various reactant ratio, other temperature, ultrasound promotion;

DOI:10.1021/ja962990n

Reference yield:

chloro-trimethyl-silane (75-77-4) + dibromodifluoromethane (75-61-6) → [bromo(difluoro)methyl]-trimethyl-silane (115262-01-6) + [chloro(difluoro)methyl]trimethylsilane (115262-00-5)

Guidance literature:

With 1-methyl-pyrrolidin-2-one; aluminium; Ambient temperature;

DOI:10.1021/ja962990n

Reference yield: 93.0%

C20H21NO2 + [bromo(difluoro)methyl]-trimethyl-silane (115262-01-6) → C21H21F2NO2

Guidance literature:

C₂₀H₂₁NO₂; With lithium hydroxide; In toluene; at 15 ℃; for 0.0833333h;

[bromo(difluoro)methyl]-trimethyl-silane; In toluene; at 15 ℃; for 24h; regioselective reaction;

DOI:10.1055/a-1507-5878

upstream raw materials:

chloro-trimethyl-silane

halon-1211

dibromodifluoromethane

Downstream raw materials:

[chloro(difluoro)methyl]trimethylsilane

1,1-difluoro-1-iodo-2-phenylethane

C₈H₇BrF₂Zn

1-bromo-2-(2,2-difluoro-2-iodoethyl)benzene

Refernces