DICHLORO N,N-DIETHYLPHOSPHORAMIDITE

Base Information

• Chemical Name: DICHLORO N,N-DIETHYLPHOSPHORAMIDITE
• CAS No.: 1498-54-0
• Molecular Formula: C4H10 Cl2 N O P
• Molecular Weight: 190.009
• Hs Code.: 2929902000
• Mol file: 1498-54-0.mol

Synonyms:Phosphoramidicdichloride, diethyl- (6CI,7CI,8CI,9CI); Dichloro(diethylamino)phosphine oxide;Dichlorodiethylphosphoramidite; Diethylphosphoramidic dichloride;Diethylphosphoramidoyl dichloride; N,N-Diethylphosphoramidic dichloride; NSC98709; P,P-Dichloro-N,N-diethylphosphinic amide

Chemical Property of DICHLORO N,N-DIETHYLPHOSPHORAMIDITE

Chemical Property:

• Vapor Pressure: 0.191mmHg at 25°C
• Melting Point: >93.3 °C
• Refractive Index: 1.4640
• Boiling Point: 210.6°Cat760mmHg
• PKA: -6.11±0.70(Predicted)
• Flash Point: 81.2°C
• PSA: 30.12000
• Density: 1.277g/cm³
• LogP: 2.91390
• Sensitive.: Moisture Sensitive

Purity/Quality:

98% ^*data from raw suppliers

Diethylphosphoramidicdichloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DICHLORO N,N-DIETHYLPHOSPHORAMIDITE

There total 7 articles about DICHLORO N,N-DIETHYLPHOSPHORAMIDITE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

diethylamine (109-89-7) → N,N-diethylphosphoramidous dichloride (1498-54-0)

Guidance literature:

With triethylamine; trichlorophosphate; In dichloromethane; for 24h; Ambient temperature;

DOI:10.1021/jm00114a014

Reference yield:

→ N,N-diethylphosphoramidous dichloride (1498-54-0)

Guidance literature:

With phosphorus pentachloride; at 130 ℃;

Reference yield:

N-chlorodiethylamine (5775-33-7) → N,N-diethylphosphoramidous dichloride (1498-54-0)

Guidance literature:

With sulfur dioxide; phosphorus trichloride; In tetrachloromethane;

upstream raw materials:

diethyl amine hydrochloride

diethylamine

N-chlorodiethylamine

diethylphosphoramidous dichloride

Downstream raw materials:

Diethylamido-phosphorsaeure-bis-ethylenimid

cyano-phosphonic acid ethyl ester-diethylamide

N,N-diethyl-N',N''-diphenyl-phosphamide

bis(4-methoxyphenyl)phosphinic acid

Refernces

• 1、 Costes et al.. "". . p. 829. Retrieved 1978.
• 2、 Harger, Martin J. P.. "A new mechanism for nucleophilic substitution at a thiophosphoryl centre revealed by the reaction of diisopropylamine with PSCl3". . p. 2863 - 2865. Retrieved 2005.
• 3、 Nunez, Andres,Berroteran, Dyanna,Nunez, Oswaldo. "Hydrolysis of cyclic phosphoramides. Evidence for syn lone pair catalysis". . p. 2283 - 2289. Retrieved 2007/10/03.