Dichloro(diethylamino)phosphine

Base Information

• Chemical Name: Dichloro(diethylamino)phosphine
• CAS No.: 1069-08-5
• Molecular Formula: C4H10Cl2NP
• Molecular Weight: 174.01
• Hs Code.: 29310099
• European Community (EC) Number: 628-166-5
• DSSTox Substance ID: DTXSID90369830
• Nikkaji Number: J80.138K
• Wikidata: Q72461799
• Mol file: 1069-08-5.mol

Synonyms:1069-08-5;Diethylphosphoramidous dichloride;Dichloro(diethylamino)phosphine;N-dichlorophosphanyl-N-ethylethanamine;diethylaminodichlorophosphine;DIETHYLPHOSPHORAMIDOUSDICHLORIDE;(Diethylamino)phosphonous Dichloride;Phosphoramidous dichloride, diethyl-;1,1-dichloro-N,N-diethylphosphinamine;(Diethylamido)dichlorophosphite;Dichlorophosphorous diethylamide;(Diethylamino)phosphine dichloride;Et2NPCl2;(dichlorophosphanyl)diethylamine;SCHEMBL2188113;DTXSID90369830;BPEMCEULJQTJMI-UHFFFAOYSA-N;BAA06908;BCP22489;MFCD00013614;AKOS003634052;Diethylphosphoramidous dichloride, 97%;D3244;FT-0633277;F20420;J-001674

Chemical Property of Dichloro(diethylamino)phosphine

Chemical Property:

• Appearance/Colour: Clear colorless to light yellow liquid
• Vapor Pressure: 0.962mmHg at 25°C
• Refractive Index: n20/D 1.497(lit.)
• Boiling Point: 179 °C at 760 mmHg
• PKA: -1.49±0.70(Predicted)
• Flash Point: 82.8 °C
• PSA: 16.83000
• Density: 1.196 g/mL at 25 °C(lit.)
• LogP: 3.03270
• Storage Temp.: 0-6°C
• Sensitive.: Moisture Sensitive
• Water Solubility.: Reacts violently in water.
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 172.9927917
• Heavy Atom Count: 8
• Complexity: 56

Purity/Quality:

99% ^*data from raw suppliers

Diethylphosphoramidous dichloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-43-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(CC)P(Cl)Cl
• Uses: DIETHYLPHOSPHORAMIDOUS DICHLORIDE is a useful reagent for the efficient phosphorylation of alcohols. Dichloro(diethylamino)phosphine is used as a reagent for the preparation of diethylaminophosphine-metal complexes and it is a critical starting material in the preparation of various phosphines, phosphoramidites & the phosphitylation of alcohols. Reagent for the preparation of diethylaminophosphine-metal complexes and the phosphitylation of alcohols.

Technology Process of Dichloro(diethylamino)phosphine

There total 19 articles about Dichloro(diethylamino)phosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

diethylamine (109-89-7) → diethylphosphoramidous dichloride (1069-08-5)

Guidance literature:

With phosphorus trichloride; In diethyl ether; at -78 - 20 ℃; for 2h;

Reference yield: 92.0%

bis(diethylamino)chlorophosphine (685-83-6) → diethylphosphoramidous dichloride (1069-08-5) + tris(diethylamino)iodophosphonium triiodide (64674-06-2)

Guidance literature:

With iodine; In diethyl ether;

Reference yield: 91.0%

1,4-Butandiylbis (86926-30-9) → diethylphosphoramidous dichloride (1069-08-5) + 1,4-Butandiylbis(dichlorphosphan) (28240-71-3)

Guidance literature:

With phosphorus trichloride; for 1h; Ambient temperature;

upstream raw materials:

diethylamine

N,N-diethylaminodibenzylphosphine

N,N-diethyl-1,1,1-trimethylsilanamine

difluoro diethylamino phosphine

Downstream raw materials:

hexaethylphosphoric triamide

trans-4-Cyclohexyl-1-diethylamino-1,4-dihydro-4-methoxyphosphorin

1-Diethylamino-1-methoxy-4-phenyl-λ⁵-phosphorin

bis(o-acetylphenyl) diethylamidophosphite

Refernces

• 1、 Herrera, Daniel,Peral, Daniel,Cordón, Mercedes,Bayón, J. Carles. "Systematic Study of the Stereoelectronic Properties of Trifluoromethylated Triarylphosphines and the Correlation of their Behaviour as Ligands in the Rh-Catalysed Hydroformylation". supporting information. p. 354 - 363. Retrieved 2020/12/30.
• 2、 Borucki, Stefan,Kelemen, Zsolt,Maurer, Martin,Bruhn, Clemens,Nyulászi, László,Pietschnig, Rudolf. "Stereochemical Alignment in Triphospha[3]ferrocenophanes". . p. 10438 - 10450. Retrieved 2017/08/07.