4-Chloro-2-methoxyphenol

Base Information Edit

Chemical Name:4-Chloro-2-methoxyphenol
CAS No.:16766-30-6
Molecular Formula:C7H7ClO2
Molecular Weight:158.584
Hs Code.:29095000
European Community (EC) Number:627-256-1
DSSTox Substance ID:DTXSID0074974
Nikkaji Number:J630.332C
Wikidata:Q72489583
ChEMBL ID:CHEMBL3416134
Mol file:16766-30-6.mol

Synonyms:4-chloroguaiacol

Suppliers and Price of 4-Chloro-2-methoxyphenol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Chloro-2-methoxyphenol
10g
$ 220.00

TRC
4-Chloro-2-methoxyphenol
2.5g
$ 85.00

TCI Chemical
4-Chloro-2-methoxyphenol >98.0%(GC)
5g
$ 61.00

SynQuest Laboratories
4-Chloro-2-methoxyphenol 98%
1 g
$ 28.00

Sigma-Aldrich
4-Chloro-2-methoxyphenol technical grade
5g
$ 40.80

Oakwood
4-Chloro-2-methoxyphenol 98%
1g
$ 14.00

Frontier Specialty Chemicals
4-Chloro-2-methoxyphenol 98%
5g
$ 41.00

Crysdot
4-Chloro-2-methoxyphenol 97%
25g
$ 138.00

ChemScene
4-Chloroguaiacol 99.56%
25g
$ 119.00

ChemScene
4-Chloroguaiacol 99.56%
10g
$ 50.00

Total 37 raw suppliers

Chemical Property of 4-Chloro-2-methoxyphenol Edit

Chemical Property:

Appearance/Colour:clear pale yellow to light brown liquid
Vapor Pressure:0.0218mmHg at 25°C
Melting Point:16-17 °C(lit.)
Refractive Index:n20/D 1.559(lit.)
Boiling Point:242.425 °C at 760 mmHg
PKA:9.52±0.18(Predicted)
Flash Point:100.415 °C
PSA：29.46000
Density:1.281 g/cm³
LogP:2.05420
Storage Temp.:Inert atmosphere,Room Temperature
Water Solubility.:It is slightly soluble in water.
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:158.0134572
Heavy Atom Count:10
Complexity:108

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Chloro-2-methoxyphenol ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:COC1=C(C=CC(=C1)Cl)O
Uses 4-Chloro-2-methoxyphenol, is used as an intermediate in pharmaceutical research, pharmaceutical chemicals and reagents. It is also used as an application intermediate. it can be used to produce 4-Chloro-2-methoxy-6-nitrophenol.

Technology Process of 4-Chloro-2-methoxyphenol

There total 10 articles about 4-Chloro-2-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 90-05-1
2-methoxy-phenol

: 16766-30-6
4-Chloroguaiacol

Guidance literature:: With oxygen; lithium chloride; copper dichloride; In acetic acid; at 60 ℃; for 6h; regioselective reaction;
DOI:10.1021/acs.jafc.7b04418

Reference yield: 90.0%

: 851344-49-5
1-(allyloxy)-4-chloro-2-methoxybenzene

: 16766-30-6
4-Chloroguaiacol

Guidance literature:: 1-(allyloxy)-4-chloro-2-methoxybenzene; With tert.-butyl lithium; In diethyl ether; pentane; at -78 ℃; for 2h; Inert atmosphere;

With methanol; In diethyl ether; pentane; at -78 ℃; Inert atmosphere;
DOI:10.1055/s-2008-1077962

Reference yield: 44.0%

: 90-05-1
2-methoxy-phenol

: 16766-30-6
4-Chloroguaiacol

: 72403-03-3
2-methoxy-6-chlorophenol

Guidance literature:: 2-methoxy-phenol; With toluene-4-sulfonic acid; In water; acetonitrile; at 20 ℃; for 0.0833333h;

With N-chloro-succinimide; In water; acetonitrile; at 20 ℃; for 2h; regioselective reaction;
DOI:10.1016/j.tet.2010.06.041