N-Ethylpropylamine

Base Information

• Chemical Name: N-Ethylpropylamine
• CAS No.: 20193-20-8
• Molecular Formula: C5H13N
• Molecular Weight: 87.1649
• Hs Code.: 2921199090
• European Community (EC) Number: 243-573-4
• DSSTox Substance ID: DTXSID2066565
• Nikkaji Number: J46.574G
• Wikidata: Q6036773
• Mol file: 20193-20-8.mol

Synonyms:N-Ethylpropylamine;20193-20-8;N-ethylpropan-1-amine;1-Propanamine, N-ethyl-;Ethylpropylamine;N-Ethyl-n-propylamine;Propylamine, N-ethyl-;ethyl(propyl)amine;ethyl-propyl-amine;propylethylamine;EINECS 243-573-4;EC 243-573-4;N-Ethylpropanamine;N-Propyl-N-ethylamine;n-ethyl-1-propanamine;N-propylethylamine;ethyl-n-propylamine;N-ethyl-propanamine;N,N-Ethylpropylamine;N-ethyl-1-propylamine;DTXSID2066565;N-Ethyl-N-propylamine, AldrichCPR;AMY13343;MFCD00015198;AKOS000154664;BP-10897;E0351;FT-0689251;EN300-35035;F21346;Q6036773;W-110511;Z138446288

Chemical Property of N-Ethylpropylamine

Chemical Property:

• Appearance/Colour: colorless transparent liquid
• Vapor Pressure: 185mmHg at 25°C
• Melting Point: -75°C (estimate)
• Refractive Index: 1.3950-1.3980
• Boiling Point: 61.499 °C at 760 mmHg
• PKA: 10.76±0.19(Predicted)
• Flash Point: -5.054 °C
• PSA: 12.03000
• Density: 0.727 g/cm³
• LogP: 1.39680
• Storage Temp.: Refrigerator
• Solubility.: Chloroform, Ethyl Acetate
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 87.104799419
• Heavy Atom Count: 6
• Complexity: 19.9

Purity/Quality:

99.9% ^*data from raw suppliers

N-Ethylpropylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,T,C
• Hazard Codes: F,T,C
• Statements: 34-11-37-35-24-20/22
• Safety Statements: 26-36/37/39-45-20

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCNCC
• Uses: N-Ethylpropylamine is used in the synthesis of neuraminidase inhibitors as well as non-peptide CRF-1 antagonists.

Technology Process of N-Ethylpropylamine

There total 23 articles about N-Ethylpropylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

propan-1-ol (71-23-8) + ethylamine (75-04-7,85404-22-4) → ethylpropylamine (20193-20-8)

Guidance literature:

With chloro(η⁵-pentamethylcyclopentadienyl)(L-prolinato)iridium(III); In toluene; at 100 ℃; for 24h;

Reference yield: 15.0%

ethylidene-propyl-amine (20577-33-7) → ethylpropylamine (20193-20-8) + (2S,3R)-N,N'-Dipropyl-butane-2,3-diamine (118792-83-9) + (2S,3S)-N,N'-Dipropyl-butane-2,3-diamine (118792-82-8,118792-83-9)

Guidance literature:

With titanium tetrachloride; magnesium; mercury dichloride; In tetrahydrofuran; at 0 ℃; for 12h; Yields of byproduct given;

DOI:10.1055/s-1988-27536

Reference yield:

propylamine (107-10-8,42939-71-9) + ethylamine (75-04-7,85404-22-4) → ethylpropylamine (20193-20-8) + di-n-propylamine (142-84-7) + diethylamine (109-89-7)

Guidance literature:

With Pt on TiO₂; In water; for 20h; Ambient temperature;

DOI:10.1021/ja00362a032

upstream raw materials:

ethyl-propyliden-amine

ethylidene-propyl-amine

N-ethylpropionamide

N-benzyl-N-ethylpropan-1-amine

Downstream raw materials:

2-{5-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-3-yl}-N-(3-fluorophenyl)acetamide

3-{[(16β,17β)-3-[(ethyl(propyl)amino)methyl]-17-hydroxyestra-1-(10),2,4-trien-16-yl]methyl}benzamide

N-ethyl-2-phenyl-N-propylethanethioamide

C₂₇H₃₄N₂O₂

Refernces

• 1、 -. "PROCESS FOR PREPARING AMINES BY HOMOGENEOUSLY CATALYZED ALCOHOL AMINATION IN THE PRESENCE OF A COMPLEX CATALYST COMPRISING IRIDIUM AND AN AMINO ACID". Paragraph 0150. . Retrieved 2014/03/21.
• 2、 -. "2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION". . . Retrieved 2008/06/13.