2-bromo-N,N-diethyl-acetamide

Base Information

• Chemical Name: 2-bromo-N,N-diethyl-acetamide
• CAS No.: 2430-01-5
• Molecular Formula: C6H12 Br N O
• Molecular Weight: 194.071
• Hs Code.: 2924199090
• Mol file: 2430-01-5.mol

Synonyms:2-Bromo-N,N-diethylacetamide;N,N-Diethyl-2-bromoacetamide; N,N-Diethyl-a-bromoacetamide; N,N-Diethylbromoacetamide; N-(Bromoacetyl)diethylamine;NSC 15092; a-Bromo-N,N-diethylacetamide

Chemical Property of 2-bromo-N,N-diethyl-acetamide

Chemical Property:

• Vapor Pressure: 0.122mmHg at 25°C
• Boiling Point: 219°Cat760mmHg
• Flash Point: 86.2°C
• PSA: 20.31000
• Density: 1.337g/cm³
• LogP: 1.24970

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-N,N-diethylacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-bromo-N,N-diethyl-acetamide

There total 7 articles about 2-bromo-N,N-diethyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

diethylamine (109-89-7) + 2-Bromoacetyl bromide (598-21-0) → 2-bromo-N,N-diethylacetamide (2430-01-5)

Guidance literature:

In dichloromethane; at -60 - 20 ℃; for 1h;

DOI:10.1021/ja910631u

Reference yield: 94.0%

2-bromoacetyl chloride (22118-09-8) + diethylamine (109-89-7) → 2-bromo-N,N-diethylacetamide (2430-01-5)

Guidance literature:

With sodium hydrogencarbonate; In chloroform; water; at 0 - 20 ℃;

DOI:10.1016/j.bmcl.2014.05.064

Reference yield: 27.0%

N-ethyl-N,N-diisopropylamine (7087-68-5) + 2-Bromoacetyl bromide (598-21-0) → 2-bromo-N,N-diethylacetamide (2430-01-5)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 1.5h;

upstream raw materials:

diethylamine

2-Bromoacetyl bromide

2-Chloro-N,N-diethylacetamide

bromoacetic acid

Downstream raw materials:

(1-hydroxy-cyclohexyl)-acetic acid diethylamide

4-methoxy-cinnamic acid diethylamide

(N,N-dicarbamoylmethyl) diphenyldithiophosphinate

β-hydroxy-isovaleric acid diethylamide

Refernces

• 1、 Muzaffar, Saima,Shahid, Wardah,Riaz, Naheed,Saleem, Muhammad,Ashraf, Muhammad,Aziz-ur-Rehman,Bashir, Bushra,Kaleem, Ayesha,al-Rashida, Mariya,Baral, Bikash,Bhattarai, Keshab,Gross, Harald. "Probing phenylcarbamoylazinane-1,2,4-triazole amides derivatives as lipoxygenase inhibitors along with cytotoxic, ADME and molecular docking studies". . . Retrieved 2021.
• 2、 Bashir, Bushra,Shahid, Wardah,Ashraf, Muhammad,Saleem, Muhammad,Aziz-ur-Rehman,Muzaffar, Saima,Imran, Muhammad,Amjad, Hira,Bhattarai, Keshab,Riaz, Naheed. "Identification of phenylcarbamoylazinane-1,3,4-oxadiazole amides as lipoxygenase inhibitors with expression analysis and in silico studies". . . Retrieved 2021.
• 3、 Pisella, Guillaume,Gagnebin, Alec,Waser, Jerome. "Copper-catalyzed oxyvinylation of diazo compounds". supporting information. p. 3884 - 3889. Retrieved 2020/05/14.