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Name	Hordenine hydrochloride	EINECS	227-892-6
CAS No.	6027-23-2	Density	N/A
PSA	23.47000	LogP	2.29830
Solubility	N/A	Melting Point	178 °C
Formula	C₁₀H₁₅NO^.HCl	Boiling Point	270.2 °C at 760 mmHg
Molecular Weight	201.696	Flash Point	123.5 °C
Transport Information	N/A	Appearance	N/A
Safety	26-36/37/39	Risk Codes	36/37/38
Molecular Structure		Hazard Symbols	Xi
Synonyms	Hordenine hydrochloride;Hordeninehydrochloride (6CI);Phenol, 4-[2-(dimethylamino)ethyl]-, hydrochloride (9CI);Phenol, p-[2-(dimethylamino)ethyl]-, hydrochloride (8CI);N,N-Dimethyltyraminehydrochloride;	Article Data	4

Hordenine hydrochloride Synthetic route

: N,N-dimethyl-p-hydroxyphenylacetamide

: 6027-23-2
2-(4-methoxyphenyl)-N,N-dimethylethylamine hydrochloride

Conditions

Conditions	Yield
Stage #1: N,N-dimethyl-p-hydroxyphenylacetamide With sodium tetrahydroborate; boron trifluoride-tetrahydrofuran complex In tetrahydrofuran at 50 - 60℃; for 4h; Stage #2: With hydrogenchloride In tetrahydrofuran; water Concentration; Reagent/catalyst;	81.2%

: 34603-52-6
1-[2-(dimethylamino)ethyl]-4'-methoxy-2,3-dihydro-[1,1′-biphenyl]-4(1H)-one

: 6027-23-2
2-(4-methoxyphenyl)-N,N-dimethylethylamine hydrochloride

Conditions

Conditions	Yield
sublimation in the presence of NH4Cl;

: 6027-23-2
2-(4-methoxyphenyl)-N,N-dimethylethylamine hydrochloride

: 539-15-1
N,N-dimethyltyramine

Conditions

Conditions	Yield
With hydrogen bromide at 120 - 130℃;	71.54%

: 2105-94-4
4-bromo-2-fluorophenol

: 1235035-65-0
2-chloro-5-((2-trimethylsilylethoxy)methoxy)pyridine

: 1235036-21-1
(Z)-tert-butyl 3-(3-hydroxypropyl)-6-(8-(3-((2-(trimethylsilyl)ethoxy)methyl)benzo[d]thiazol-2(3H)-ylidenecarbamoyl)-3,4-dihydroisoquinolin-2(lH)-yl)picolinate

: 6027-23-2
2-(4-methoxyphenyl)-N,N-dimethylethylamine hydrochloride

: 1235034-29-3
6-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(4-(2-dimethylaminoethyl)phenoxy)propyl)picolinic acid

Conditions

Conditions	Yield
Stage #1: 4-bromo-2-fluorophenol; (Z)-tert-butyl 3-(3-hydroxypropyl)-6-(8-(3-((2-(trimethylsilyl)ethoxy)methyl)benzo[d]thiazol-2(3H)-ylidenecarbamoyl)-3,4-dihydroisoquinolin-2(lH)-yl)picolinate With di-tert-butyl (E)-azodicarboxylate; triphenylphosphine In tetrahydrofuran for 2h; Stage #2: 2-chloro-5-((2-trimethylsilylethoxy)methoxy)pyridine With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide In N,N-dimethyl-formamide at 100℃; Stage #3: 2-(4-methoxyphenyl)-N,N-dimethylethylamine hydrochloride

Yield

Stage #1: 4-bromo-2-fluorophenol; (Z)-tert-butyl 3-(3-hydroxypropyl)-6-(8-(3-((2-(trimethylsilyl)ethoxy)methyl)benzo[d]thiazol-2(3H)-ylidenecarbamoyl)-3,4-dihydroisoquinolin-2(lH)-yl)picolinate With di-tert-butyl (E)-azodicarboxylate; triphenylphosphine In tetrahydrofuran for 2h;
Stage #2: 2-chloro-5-((2-trimethylsilylethoxy)methoxy)pyridine With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide In N,N-dimethyl-formamide at 100℃;
Stage #3: 2-(4-methoxyphenyl)-N,N-dimethylethylamine hydrochloride

Hordenine hydrochloride Chemical Properties

Molecular Structure:

Molecular Formula: C₁₀H₁₆ClNO
Molecular Weight: 201.6931
IUPAC Name: 4-(2-Dimethylaminoethyl)phenol hydrochloride
Synonyms of Hordenine hydrochloride (CAS NO.6027-23-2): 2-(4-Hydroxyphenyl)-N,N'-dimethylethylamine hydrochloride ; 4-[2-(Dimethylamino)ethyl]phenol hydrochloride
CAS NO: 6027-23-2
Product Categories: Drug / Therapeutic Agent
Melting point: 178 °C
Flash Point: 123.5 °C
Enthalpy of Vaporization: 52.89 kJ/mol
Boiling Point: 270.2 °C at 760 mmHg
Vapour Pressure: 0.00417 mmHg at 25°C

Hordenine hydrochloride Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mammal (species unspecified)	LD50	subcutaneous	10mg/kg (10mg/kg)		Journal of the Chemical Society. Vol. -, Pg. 191, 1947.
mouse	LD50	unreported	114mg/kg (114mg/kg)		"Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 750, 1989.

Hordenine hydrochloride Safety Profile

Hazard Codes of Hordenine hydrochloride (CAS NO.6027-23-2): Irritant Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
Hazard Note: Irritant

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