TAME5OX, abiotic siderophore analogue to enterobactin involving 8-Hydroxyquinoline (cas 148-24-3) subunits: Thermodynamic and photophysical studies

Add time:09/30/2019    Source:infona.pl

The synthesis, thermodynamic and photophysical properties of trivalent metal complexes of biomimetic nonadentate analogue, 5,5′-(2-(((8-hydroxyquinolin-5-yl)methylamino)methyl)-2-methylpropane-1,3-diyl)bis(azanediyl)bis(methylene)diquinolin-8-ol (TAME5OX), have been described. Combination of absorption and emission spectrophotometry, potentiometry, electrospray mass spectrometry, IR, and theoretical investigation were used to fully characterize metal (Fe +3 , Al +3 and Cr +3 ) chelates of TAME5OX. In solution, TAME5OX forms protonated complexes [M(H 3 L)] 3+ below pH 3.4, which consecutively deprotonates through one to three-proton processes with rise of pH. The formation constants (Logβ 11n ) of neutral complexes formed at or above physiological pH, have been determined to be 30.18, 23.27 and 22.02 with pM values of 31.16, 18.07 and 18.12 for Fe +3 , Al +3 and Cr +3 ions, respectively, calculated at pH 7.4, indicating TAME5OX is a powerful among synthetic metal chelator. The results clearly demonstrate that the ligand in a tripodal orchestration firmly binds these ions over wide pH range and forms distorted octahedral complexes. The binding and the coordination event could be monitored from absorption and fluorescence spectroscopy. The high thermodynamic stability in water at physiological pH of ferric complex of TAME5OX indicates that these complexes are resistant to hydrolysis and therefore are well suited for the development of device for applications as probes. The ligand displays high sensitive fluorescence enhancement to Al 3+ at pH 7.4, in water. Moreover, TAME5OX can distinguish Al 3+ from Fe 3+ and Cr 3+ via two different sensing mechanisms: photoinduced electron transfer (PET) for Al 3+ and internal charge transfer (ICT) for Fe 3+ and Cr 3+ . Density functional theory was employed for optimization and evaluation of vibrational modes, NBO analysis, excitation and emission properties of the different species of metal complexes observed by solution studies.

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