Variations of HUPERZINE (cas 116-28-9) A content in Lycopodiaceae species from tropics

Add time:08/27/2019    Source:sciencedirect.com

(−) HUPERZINE (cas 116-28-9) A is a bioactive alkaloid from Huperzia serrata (Lycopodiaceae) used for the treatment of Alzheimer's disease. High yielding (−) huperzine A species is of interest for mass propagation since it grows slowly in temperate countries. The content of (−) huperzine A from temperate countries was reported but none reported from tropical species. The aim of this study was to evaluate the content of (−) huperzine A from tropical club mosses and further identify a high yielding species. Club mosses from Lycopodiaceae family were collected from Peninsular Malaysia. The collected club mosses were dried, pulverized and extracted with methanol. A gradient reverse phase HPLC-photodiode array detector method with increasing amount of methanol in 0.01 % trifluoroacetic acid was developed. The calibration curve was linear from 5 to 100 μgmL−1 with correlation coefficient, r2, of 0.998 1. The precision for both intra- and inter-day peak area were between 0.48% to 1.24 % and 0.95% to 3.85 %, respectively. The recovery of the method was between 99.8% to 103.8 %. Though geographically segregated, (−) huperzine A content in Huperzia phlegmaria and H.carinata found in the tropics was highest and similar to species in Australasia. Both species may provide a good source of (−) huperzine A.

We also recommend Trading Suppliers and Manufacturers of HUPERZINE (cas 116-28-9). Pls Click Website Link as below: cas 116-28-9 suppliers

Prev:Microbial transformation of (−)-HUPERZINE (cas 116-28-9) A
Next:A combination of [+] and [−]-HUPERZINE (cas 116-28-9) A improves protection against soman toxicity compared to [+]-HUPERZINE (cas 116-28-9) A in guinea pigs)