Layer by layer assembled phosphorylcholine (cas 107-73-3) groups on paclitaxel/chitosan nanofibers coatings for hemocompatibility improvement

Add time:08/22/2019    Source:sciencedirect.com

A novel layer by layer (LbL) assembled structure with phosphorylcholine (cas 107-73-3) groups was fabricated to improve the hemocompatibility of paclitaxel/chitosan (PTX/CS) nanofibers (NF) coatings The random copolymers with phosphorylcholine groups poly (2‑methacryloyloxy-ethylphosphorylcholine‑co‑methacrylicacid) (PMAs) were synthesized through free radical polymerization and then first PMA layer formed on PTX/CS NF coatings via electrostatic interactions. After that CS polycation and PMA polyanion thin films LbL formed on PTX/CS NF coatings. The LbL structure was confirmed by X-ray photoelectron spectroscopy (XPS) and water contact angle. The drug release in vitro indicated that the PMA modified PTX/CS NF coatings (PTX/CS-PMA NF coatings) showed a sustained slower release of PTX drug. The LbL coatings containing phosphorylcholine groups could significantly reduce proteins adsorption, platelets adhesion and cell adhesion. They showed a lower platelet (about 6%) and protein (30–40%) (bovine serum albumin, BSA; bovine plasma fibrinogen, Fg) adhesion. Meanwhile, the adhesion of human umbilical vein endothelial cells (HUVECs) was also found reduced. These results demonstrate that the preparation of PMA modified coatings is a simple strategy to improve the hemocompatibility of PTX/CS NF coatings, has good potential for application in blood-contacting materials and devices.

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