DNA interaction, cellular localization and cytotoxicity of Quinacridone (cas 1047-16-1) derivatives

Add time:07/26/2019    Source:sciencedirect.com

Quinacridone (cas 1047-16-1) derivatives (QAs) are widely used in industrial colorant, chemical sensors and organic optoelectronic devices; however their biological applications are rarely reported. Here we describe the interaction of QAs with different DNA forms and cancer cells. Quinacridone and N,N'-bis(5-bromopentyl) quinacridone (QAB) selectively bind parallel G-quadruplex DNA through end-stacking. N,N'-bis(methylpiperazinylpentyl) quinacridone (QAP) and N,N'-bis(dimethyl-aminopentyl) quinacridone (QAT) strongly bind all DNA forms through hydrogen bonding and electrostatic interaction of the alkylamine side chains and DNA. Quinacridone does not enter living cells; QAB enters living cells and mainly locates in lysosome; QAP and QAT enter living cells and locate in whole cells, especially in nuclei through binding DNA. However, these QAs do not show significant cytotoxicity. These results suggest that side chains greatly affect the DNA interaction, cellular permeability and localization of QAs, and provide useful information for the design of DNA-binding drugs and fluorescent probes.

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