99848-45-0

Basic information

• Product Name: 1-chloro-2-iodo-3,5-dimethoxybenzene
• Synonyms: 1-chloro-2-iodo-3,5-dimethoxybenzene
• CAS NO: 99848-45-0
• Molecular Weight: 298.508
• Mol File: 99848-45-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-chloro-2-iodo-3,5-dimethoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-chloro-2-iodo-3,5-dimethoxybenzene(99848-45-0)
• EPA Substance Registry System: 1-chloro-2-iodo-3,5-dimethoxybenzene(99848-45-0)

Safety Data

• Hazardous Substances Data: 99848-45-0(Hazardous Substances Data)

Usage

Structure

Substituted benzene derivative with chlorine, iodine, and methoxy groups

Applications

a. Organic synthesis
b. Preparation of pharmaceuticals and fine chemicals
c. Intermediate in the production of various organic compounds
d. Building block for synthesis of complex molecules
e. Potential use in pharmaceutical and agrochemical industries

Reactivity

Useful intermediate due to its specific properties and reactivity

Industry relevance

Range of potential uses in organic chemistry and related industries

Upstream product

• 7051-16-3 1-chloro-3,5-dimethoxybenzene 
• 82485-84-5 6-amino-5-chloro-1,3-dimethoxybenzene 

Downstream Products

• 1028332-16-2 2-(2-chloro-4,6-dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1335243-60-1 1-chloro-2-cyclohex-1-enylethynyl-3,5-dimethoxybenzene 
• 1335243-59-8 1-chloro-2-hex-1-ynyl-3,5-dimethoxybenzene 

Relevant articles and documents

Practical and metal-free electrophilic aromatic halogenation by interhalogen compounds generated in situ from N-halosuccinimide and catalytic TMSCL

Halomonochloride compounds (ClCl, BrCl, ICl) generated in situ from N-halosuccinimide and catalytic chlorotrimethylsilane (TMSCl, 0.1 equiv) can efficiently halogenate aromatic compounds to give halogenated products in good to excellent yields and selectivities. The reaction can be carried out at room temperature or at lower temperatures, requires only one hour, is practical to apply to a wide range of substrates, and provides a simple access to a variety of haloarene compounds. Georg Thieme Verlag Stuttgart New York.

2-AMINO PYRIDINE COMPOUNDS

The present invention is directed to 2-aminopyrimidine compounds and pharmaceutically acceptable salts thereof, their synthesis and their use as HSP-90 inhibitors.