99477-24-4

Basic information

• Product Name: 4-bromoestra-1,3,5(10)-triene-3,16α,17β-triol
• Synonyms: 4-bromoestra-1,3,5(10)-triene-3,16α,17β-triol
• CAS NO: 99477-24-4
• Molecular Weight: 367.283
• Mol File: 99477-24-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-bromoestra-1,3,5(10)-triene-3,16α,17β-triol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromoestra-1,3,5(10)-triene-3,16α,17β-triol(99477-24-4)
• EPA Substance Registry System: 4-bromoestra-1,3,5(10)-triene-3,16α,17β-triol(99477-24-4)

Safety Data

• Hazardous Substances Data: 99477-24-4(Hazardous Substances Data)

Upstream product

• 19590-54-6 2,4-dibromoestratriol 

Relevant articles and documents

Synthesis of 2-Methoxy- and 4-Methoxy-Estrogens with Halogen-Methoxy Exchange Reaction

Synthesis of 2-methoxy- and 4-methoxy-estrone (6) and (9), 2-methoxy- and 4-methoxy-estradiol (15) and (18), and 2-methoxy- and 4-methoxy-estratriol (24) and (27) are described.Catalytic hydrogenation over Pd/C of 2,4-dibromo or 2,4-diiodo estrogens gave regioselectively the corresponding 4-halogeno derivatives in excellent yields.Reaction of 2-iodo or 4-iodo estradiol and 2-iodo or 4-iodo estriol with NaOCH3 in MeOH and dimethylformamide (DMF) in the presence of CuCl2 gave in an excellent yield and in a good yield, while (6) and (9) were also similarly obtained by the reaction with pyridine instead of DMF.