97966-00-2

Basic information

• Product Name: 5-Bromo-2,3-dichloropyridine
• Synonyms: 5-BROMO-2,3-DICHLOROPYRIDINE;2,3Dichloro-5-BromoPyridine;[4-(trifluoromethyl)-1,3-benzothiazol-2-yl]amine
• CAS NO: 97966-00-2
• Molecular Formula: C₅H₂BrCl₂N
• Molecular Weight: 226.89
• EINECS: -0
• Product Categories: Pyridine series;Heterocycle;Boronic Acid
• Mol File: 97966-00-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: 35-37°C
• Boiling Point: 55-65 C
• Flash Point: 95.1 °C
• Appearance: Off white solid
• Density: 1.848 g/cm³
• Vapor Pressure: 0.084mmHg at 25°C
• Refractive Index: 1.597
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: -3.02±0.10(Predicted)
• CAS DataBase Reference: 5-Bromo-2,3-dichloropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-2,3-dichloropyridine(97966-00-2)
• EPA Substance Registry System: 5-Bromo-2,3-dichloropyridine(97966-00-2)

Safety Data

• Hazard Codes: Xi,T
• Statements: 36/37/38-41-37/38-25
• Safety Statements: 26-45-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 97966-00-2(Hazardous Substances Data)

Usage

Chemical Properties

White crystals

InChI:InChI=1/C5H2BrCl2N/c6-3-1-4(7)5(8)9-2-3/h1-2H

Upstream product

• 98121-41-6 5-Amino-2,3-dichloropyridine 
• 22353-38-4 3-chloro-2-hydroxy-5-nitropyridine 
• 22353-40-8 2,3-dichloro-5-nitropyridine 
• 5418-51-9 5-nitro-2-hydroxypyridine 
• 15862-34-7 5-bromo-3-nitro-2-pyridone 
• 6945-68-2 5-bromo-3-nitro-pyridin-2-ylamine 
• 15862-37-0 2,5-dibromo-3-nitro-pyridine 
• 67443-38-3 5-bromo-2-chloro-3-nitropyridine 
• 588729-99-1 3-amino-5-bromo-2-chloropyridine 
• 1221793-62-9 3-bromo-5-chloropyridine N-oxide 
• 90902-84-4 2,5-dibromopyridin-3-ylamine 

Downstream Products

• 1289093-31-7 5-bromo-3-chloro-2-isobutoxypyridine 
• 1355066-42-0 5-chloro-6-isobutoxypyridin-3-ol 
• 1387634-81-2 3-chloro-2-isobutoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 
• 160599-70-2 2,5-dibromo-3-chloropyridine 
• 120800-05-7 2,3-dichloro-5-acetylpyridine 
• 799279-80-4 Sofinicline 
• 1019493-16-3 5-chloro-6-(cyclopropylmethoxy)nicotinic acid 
• 1416978-63-6 (E)-N-((3-Chloro-5-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)-but-1-en-1-yl)pyridin-2-yl)methyl)-3,3,3-trifluoropropanamide 

Relevant articles and documents

Application of 1,1-ADEQUATE, HMBC, and Density Functional Theory to Determine Regioselectivity in the Halogenation of Pyridine N-Oxides

The 1,1-ADEQUATE spectrum clearly shows specific two-bond proton to carbon correlations to unequivocally distinguish the major and minor regioisomers of ortho-halogenated pyridines and to aid in assignment of the corresponding proton and carbon chemical shifts. M06-2X/6-31+G(d,p) free energies of the regioisomeric intermediates arising from deprotonation correctly predict the experimentally observed preference and thus can be used to tune the substituent pattern to yield a desired regiochemical outcome.

(1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane is an effective analgesic agent

The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane, salts thereof, and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.

(1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane is an effective analgesic agent

The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.