97-52-9Relevant articles and documents
Preparation method of 2-methoxy-4-nitroaniline
-
Paragraph 0051; 0054; 0064; 0065; 0067-0073; 0078, (2019/06/12)
The invention discloses a preparation method of 2-methoxy-4-nitroaniline. The preparation method comprises the following steps of: carrying out acetylation reaction of o-methoxyaniline and acetic acid, discharging water generated in the acetylation reaction process from a reaction system, dropwisely adding fuming nitric acid into the prepared acetic acid solution of the o-methoxyacetanilide to carry out nitration reaction, adding deionized water after the nitration reaction is finished and then filtering, adding the prepared 2-methoxy-4-nitroaniline into an alkali solution to carry out hydrolysis reaction; after the hydrolysis reaction is finished, cooling the prepared reaction solution, and filtering to obtain 2-methoxy-4-nitroaniline. By adopting the method to synthesize 2-methoxy-4-nitroaniline, the acylation reaction cost is low, the nitration reaction selectivity is high, the discharge of three wastes is reduced, the production cost is reduced, the product purity is high, the yield is high, and the 2-methoxy-4-nitroaniline has a good industrial application value.
A PLA-TiO2 particle brush as a novel support for CuNPs: A catalyst for the fast sequential reduction and: N -arylation of nitroarenes
Barot, Nirav,Shaikh, Tauhid,Kaur, Harjinder
, p. 5347 - 5354 (2017/07/11)
The present study describes the synthesis and characterization of dispersible copper nanoparticles on a PLA-TiO2 particle brush and their catalytic efficiency in conducting sequential reactions. The prepared CuNP@PLA-TiO2 was characterized using various techniques like SEM, TEM, EDAX, FT-IR, TGA, XRD and UV-vis spectroscopy. The support controlled the size of the nanoparticles between 2-6 nm and prevented their agglomeration during catalysis. A zeta potential of -70.3 mV was measured for the dispersed catalyst, which indicated its high stability in solution. The nanoparticles were effectively used for the synthesis of biphenyl amines from nitro arenes by sequentially carrying out reduction and N-arylation in a single pot. The short reaction time of N-arylation and recyclability are the hallmark of the developed catalytic system.
Steric-Hindrance-Induced Regio- and Chemoselective Oxidation of Aromatic Amines
Patil, Vilas Venunath,Shankarling, Ganapati Subray
, p. 7876 - 7883 (2015/09/01)
Unusual regio- and chemoselective oxidation of aromatic amines hindered with ortho substituents (except -NH2, -NHCH3, and -OH) to the corresponding nitro compounds is described by use of nonanebis(peroxoic acid). The mechanistic investigation for selective oxidation of amines ortho-substituted with -NH2 or -OH showed the involvement of H-bonding between the ortho hydrogen of the adjacent -XH group (where X = NH, NR, or O) and an oxygen atom from the diperoxy acid. Various mono- and diamines are oxidized into corresponding mononitro derivatives in high yield and purity without employing any protection strategies. The protocol was also found to successful on the gram scale.