95651-19-7

Basic information

• Product Name: Phenyl [5-(trifluoromethyl)pyridin-2-yl]carbamate
• Synonyms: Phenyl [5-(trifluoromethyl)pyridin-2-yl]carbamate;(5-Trifluoromethyl-pyridin-2-yl)-carbamic acid phenyl ester
• CAS NO: 95651-19-7
• Molecular Formula: C₁₃H₉F₃N₂O₂
• Molecular Weight: 282.2179696
• Mol File: 95651-19-7.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 341.4°Cat760mmHg
• Flash Point: 160.3°C
• Appearance: /
• Density: 1.403g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.562
• CAS DataBase Reference: Phenyl [5-(trifluoromethyl)pyridin-2-yl]carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: Phenyl [5-(trifluoromethyl)pyridin-2-yl]carbamate(95651-19-7)
• EPA Substance Registry System: Phenyl [5-(trifluoromethyl)pyridin-2-yl]carbamate(95651-19-7)

Safety Data

• Hazardous Substances Data: 95651-19-7(Hazardous Substances Data)

Usage

Description

Phenyl [5-(trifluoromethyl)pyridin-2-yl]carbamate is a chemical compound characterized by the molecular formula C13H9F3N2O2. It is a carbamate derivative featuring a phenyl group and a pyridine ring, with a trifluoromethyl substituent at the 5-position. Phenyl [5-(trifluoromethyl)pyridin-2-yl]carbamate serves as a versatile intermediate in the synthesis of pharmaceuticals and agrochemicals, and its carbamate functional group contributes to its utility in the creation of organic compounds. Additionally, it holds potential for the development of new drugs and agrochemical products, although it must be handled with care due to its potential hazards.

Uses

Used in Pharmaceutical Industry:
Phenyl [5-(trifluoromethyl)pyridin-2-yl]carbamate is used as a synthetic intermediate for the development of various pharmaceuticals. Its unique structure allows for the creation of new drug candidates that can target specific biological pathways or receptors, potentially leading to more effective treatments for a range of diseases.
Used in Agrochemical Industry:
In the agrochemical sector, Phenyl [5-(trifluoromethyl)pyridin-2-yl]carbamate is utilized as a building block in the synthesis of pesticides and other crop protection agents. Its chemical properties enable the design of compounds that can effectively control pests and diseases, thereby enhancing crop yields and quality.
Used in Organic Synthesis:
Phenyl [5-(trifluoromethyl)pyridin-2-yl]carbamate is employed as a key component in organic synthesis, where it can be used to construct a variety of complex organic molecules. Its carbamate functional group facilitates the formation of new chemical bonds and the synthesis of diverse organic compounds for various applications, including materials science and specialty chemicals.

InChI:InChI=1/C13H9F3N2O2/c14-13(15,16)9-6-7-11(17-8-9)18-12(19)20-10-4-2-1-3-5-10/h1-8H,(H,17,18,19)

Upstream product

• 74784-70-6 2-amino-5-trifluoromethylpyridine 
• 1885-14-9 phenyl chloroformate 

Relevant articles and documents

PESTICIDALLY-ACTIVE MESOIONIC BICYCLIC HETEROAROMATIC COMPOUNDS

A compound of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides.

Structure-activity relationship studies and discovery of a potent transient receptor potential vanilloid (TRPV1) antagonist 4-[3-chloro-5-[(1 S)-1,2-dihydroxyethyl]-2-pyridyl]-N-[5-(trifluoromethyl)-2-pyridyl]-3, 6-dihydro-2 H-pyridine-1-carboxamide (V116517) as a clinical candidate for pain management

A series of novel tetrahydropyridinecarboxamide TRPV1 antagonists were prepared and evaluated in an effort to optimize properties of previously described lead compounds from piperazinecarboxamide series. The compounds were evaluated for their ability to block capsaicin and acid-induced calcium influx in CHO cells expressing human TRPV1. The most potent of these TRPV1 antagonists were further characterized in pharmacokinetic, efficacy, and body temperature studies. On the basis of its pharmacokinetic, in vivo efficacy, safety, and toxicological properties, compound 37 was selected for further evaluation in human clinical trials.

TRPV1 ANTAGONISTS AND USES THEREOF

The invention relates to compounds of formula (I) and pharmaceutically acceptable derivatives thereof, compositions comprising an effective amount of a compound of formula I or a pharmaceutically acceptable derivative thereof, and methods for treating or preventing a condition such as pain, UI, an ulcer, IBD and IBS, comprising administering to an animal in need thereof an effective amount of a compound of formula I or a pharmaceutically acceptable derivative thereof.