95412-13-8Relevant articles and documents
Rhodium-Catalyzed Sequential Cycloisomerization/Aldol Addition of Cyclopropene Carboxylic Acids with Isatins
Zhang, Dan,Wang, Xin,Zhang, Mengchu,Hu, Wenhao
, p. 5600 - 5604 (2020)
A unique, rhodium-catalyzed reaction of cyclopropene carboxylic acids with isatins has been developed, which takes place through a trapping process of transient cyclic carboxylic oxonium ylides. This reaction tolerates a wide variety of cyclopropene carboxylic acids and N-protected or unprotected isatins and represents a new, direct strategy to access valuable γ-substituted γ-butenolide architectures containing an oxindole moiety in very high yields under mild reaction conditions.
Cobalt-Catalyzed Vinylic C-H Addition to Formaldehyde: Synthesis of Butenolides from Acrylic Acids and HCHO
Yu, Shuling,Hong, Chao,Liu, Zhanxiang,Zhang, Yuhong
, p. 8359 - 8364 (2021/11/01)
A carboxyl-assisted C-H functionalization of acrylic acids with formaldehyde to give butenolides is described. It is the first time that the addition of an inert vinylic C-H bond to formaldehyde has been achieved via cobalt-catalyzed C-H activation. The unique reactivity of the cobalt species was observed when compared with related Rh or Ir catalysts. γ-Hydroxymethylated butenolides were produced by the treatment of Na2CO3 after the catalytic reaction in one pot.
A new regioselective synthesis of 3-substituted furan-2(5H)-ones by palladium-catalysed reductive carbonylation of alk-1-ynes
Gabriele, Bartolo,Salerno, Giuseppe,Costa, Mirco,Chiusoli, Gian Paolo
, p. 989 - 990 (2007/10/03)
3-Alkyl- or 3-aryl-substituted furan-2(5H)-ones are obtained directly in fair yields by reductive carbonylation of alk-1-ynes in the presence of catalytic amounts of palladium iodide in conjunction with potassium iodide (10 eq.) and water (200 eq.). Simultaneous oxidation of CO to CO2 accounts for the stoichiometry of the process. Reactions are carried out in dioxane under mild conditions (80 °C and 10 atm of carbon monoxide).