953039-62-8

Basic information

• Product Name: 2(1H)-Quinazolinone, 8-bromo-6-fluoro-
• Synonyms: 2(1H)-Quinazolinone, 8-bromo-6-fluoro-;8-Bromo-6-fluoroquinazolin-2(1H)-one
• CAS NO: 953039-62-8
• Molecular Formula: C8H4BrFN2O
• Molecular Weight: 243.04
• Mol File: 953039-62-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2(1H)-Quinazolinone, 8-bromo-6-fluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Quinazolinone, 8-bromo-6-fluoro-(953039-62-8)
• EPA Substance Registry System: 2(1H)-Quinazolinone, 8-bromo-6-fluoro-(953039-62-8)

Safety Data

• Hazardous Substances Data: 953039-62-8(Hazardous Substances Data)

Usage

Type of compound

chemical compound, quinazolinone derivative

Structure

fused two-ring heterocyclic compound

Substitution

8-bromo-6-fluoro

Potential use

pharmaceutical research, unique biological activities, drug candidate, starting point for further chemical modifications

Extent of study

not extensively studied

Properties and potential applications

need further research to elucidate

Upstream product

• 446-08-2 2-amino-5-fluorobenzoic acid 
• 55414-45-4 (2-amino-3-bromo-5-fluorophenyl)methanol 
• 259269-84-6 2-amino-3-bromo-5-fluorobenzoic acid 
• 953039-61-7 2-amino-3-bromo-5-fluorobenzaldehyde 
• 57-13-6 urea 

Downstream Products

• 953039-63-9 8-bromo-2-chloro-6-fluoroquinazoline 

Relevant articles and documents

CONDENSED-RING PYRIMIDYLAMINO DERIVATIVE, PREPARATION METHOD THEREFOR, AND INTERMEDIATE, PHARMACEUTICAL COMPOSITION AND APPLICATIONS THEREOF

Disclosed are a condensed-ring pyrimidylamino derivative, a preparation method therefor, and an intermediate, a pharmaceutical composition and applications thereof. The method for preparing the condensed-ring pyrimidylamino derivative comprises: in a solvent, in the presence of a palladium-containing catalyst, allowing a compound represented by formula I-a and a compound represented by formula I-b' to have a coupling reaction, and then preparing a compound represented by formula I by means of a deprotection reaction. Also disclosed applications of the condensed-ring pyrimidylamino derivative in the preparation of drugs for preventing, relieving and/or treating tumors or diseases caused by an anaplastic lymphoma kinase. The condensed-ring pyrimidylamino derivative of the present invention has an obvious restraint effect on the anaplastic lymphoma kinase.

QUINAZOLINES FOR PDK1 INHIBITION

The invention provides novel quinazoline compounds that are inhibitors of PDK1. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions.