946842-91-7

Basic information

• Product Name: methyl 2-deuterio-2-phenylbutyrate
• Synonyms: methyl 2-deuterio-2-phenylbutyrate
• CAS NO: 946842-91-7
• Molecular Weight: 179.223
• Mol File: 946842-91-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl 2-deuterio-2-phenylbutyrate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-deuterio-2-phenylbutyrate(946842-91-7)
• EPA Substance Registry System: methyl 2-deuterio-2-phenylbutyrate(946842-91-7)

Safety Data

• Hazardous Substances Data: 946842-91-7(Hazardous Substances Data)

Upstream product

• 1455-13-6 deuteromethanol 
• 119-43-7 ethyl 2-phenylbutanoate 
• 90-27-7 2-Phenylbutyric acid 
• 22979-35-7 Methyl phenyldiazoacetate 
• 557-20-0 diethylzinc 

Downstream Products

• 119067-75-3 2-deuterio-2-phenylbutanoic acid 

Relevant articles and documents

Rh(II)-Catalyzed Reactions of Diazoesters with Organozinc Reagents

Rh(II)-catalyzed reactions of diazoesters with organozinc reagents are described. Diorganozinc reagents participate in reactions with diazo compounds by two distinct, catalyst-dependent mechanisms. With bulky diisopropylethyl acetate ligands, the reaction mechanism is proposed to involve initial formation of a Rh-carbene and subsequent carbozincation to give a zinc enolate. With Rh2(OAc)4, it is proposed that initial formation of an azine precedes 1,2-addition by an organozinc reagent. This straightforward route to the hydrazone products provides a useful method for preparing chiral quaternary α-aminoesters or pyrazoles via the Paul-Knorr condensation with 1,3-diketones. Crossover and deuterium labeling experiments provide evidence for the mechanisms proposed.