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941685-26-3

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  • 941685-26-3 Structure

  • Basic information

    1. Product Name: 4-CHLORO-7-((2-(TRIMETHYLSILYL)ETHOXY)METHYL)-7H-PYRROLO[2,3-D]PYRIMIDINE
    2. Synonyms: 4-CHLORO-7-((2-(TRIMETHYLSILYL)ETHOXY)METHYL)-7H-PYRROLO[2,3-D]PYRIMIDINE;7-((2-(triMethylsilyl)ethoxy)Methyl)-4-chloro-7H-pyrrolo[2,3-d]pyriMidine;7H-Pyrrolo[2,3-d]pyriMidine, 4-chloro-7-[[2-(triMethylsilyl)ethoxy]Methyl]-
    3. CAS NO:941685-26-3
    4. Molecular Formula: C12H18ClN3OSi
    5. Molecular Weight: 283.833
    6. EINECS: 1592732-453-0
    7. Product Categories: N/A
    8. Mol File: 941685-26-3.mol
    9. Article Data: 37

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 368.3±37.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.17±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
    8. Solubility: N/A
    9. PKA: 3.00±0.30(Predicted)
    10. CAS DataBase Reference: 4-CHLORO-7-((2-(TRIMETHYLSILYL)ETHOXY)METHYL)-7H-PYRROLO[2,3-D]PYRIMIDINE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 4-CHLORO-7-((2-(TRIMETHYLSILYL)ETHOXY)METHYL)-7H-PYRROLO[2,3-D]PYRIMIDINE(941685-26-3)
    12. EPA Substance Registry System: 4-CHLORO-7-((2-(TRIMETHYLSILYL)ETHOXY)METHYL)-7H-PYRROLO[2,3-D]PYRIMIDINE(941685-26-3)

  • Safety Data

    1. Hazard Codes: Xn
    2. Statements: 22
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 941685-26-3(Hazardous Substances Data)

941685-26-3 Usage

Description

4-Chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine is a chemical compound that plays a significant role in the development of pharmaceuticals, particularly in the design and preparation of conjugate derivatives with dual inhibitory activity.

Uses

Used in Pharmaceutical Industry:
4-Chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine is used as a key intermediate in the synthesis of ruxolitinib-vorinostat conjugate derivatives. These conjugates exhibit dual inhibitory activity against Janus kinase (JAK) and histone deacetylase (HDAC), making them valuable in the development of novel therapeutic agents for various diseases, including cancer and inflammatory disorders.

Check Digit Verification of cas no

The CAS Registry Mumber 941685-26-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,1,6,8 and 5 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 941685-26:
(8*9)+(7*4)+(6*1)+(5*6)+(4*8)+(3*5)+(2*2)+(1*6)=193
193 % 10 = 3
So 941685-26-3 is a valid CAS Registry Number.

941685-26-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine

1.2 Other means of identification

Product number -
Other names 2-[(4-chloropyrrolo[2,3-d]pyrimidin-7-yl)methoxy]ethyl-trimethylsilane

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:941685-26-3 SDS

941685-26-3Relevant articles and documents

AN IMPROVED PROCESS FOR THE PREPARATION OF BARICITINIB

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Page/Page column 19, (2021/04/01)

The present invention provides an improved process for the preparation of Baricitinib of formula (I),

Chemical Compounds

-

Paragraph 0174; 0175, (2020/05/29)

The present invention describes novel compounds, or their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their medical uses. The compounds of the invention have activity as Janus Kinase inhibitors and are useful in the treatment or control of pruritus, associated with allergic dermatitis, atopic dermatitis in animals, and other disorders and indications where immunosuppression/immunomodulation would be desirable. Also described herein are methods of treating pruritus and atopic dermatitis by administering the compounds of the invention, which are JAK 1 inhibitors.

Pyrrole/imidazo six-membered hetero-aromatic ring compound as well as preparation method and medical application thereof

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Paragraph 0167-0168; 0171-0172, (2020/07/13)

The invention relates to a pyrrole/imidazo six-membered hetero-aromatic ring compound as well as a preparation method and medical application thereof. Particularly, the invention relates to a compoundas shown by general formula (I), a preparation method t

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