92950-42-0

Basic information

• Product Name: 10-Deacetyl-13-oxobaccatin III
• Synonyms: (2aR,4S,4aS,6R,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-2a,4,4a,10,11,12,12a,12b-octahydro-4,6,11-trihydroxy-4a,8,13,13-tetraMethyl-7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete-5,9(3H,6H)-dione;10-Deacetyl-13-oxobaccatin III;13-Oxo-10-deacetyl Baccatin III
• CAS NO: 92950-42-0
• Molecular Formula: C₂₉H₃₄O₁₀
• Molecular Weight: 542.57426
• Product Categories: Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 92950-42-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 205-207 °C
• Boiling Point: 720.7±60.0 °C(Predicted)
• Appearance: /
• Density: 1.41±0.1 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 11.06±0.70(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: 10-Deacetyl-13-oxobaccatin III(CAS DataBase Reference)
• NIST Chemistry Reference: 10-Deacetyl-13-oxobaccatin III(92950-42-0)
• EPA Substance Registry System: 10-Deacetyl-13-oxobaccatin III(92950-42-0)

Safety Data

• Hazardous Substances Data: 92950-42-0(Hazardous Substances Data)

Usage

Description

10-Deacetyl-13-oxobaccatin III is a novel stable derivative of 10-Deacetylbaccatin III (D198250), a naturally occurring compound with antitumor and antimitotic activity. It has been developed to enhance the stability and effectiveness of the parent compound, making it a promising candidate for various applications in the pharmaceutical and healthcare industries.

Uses

Used in Anticancer Applications:
10-Deacetyl-13-oxobaccatin III is used as an anticancer agent for its ability to inhibit tumor growth and proliferation. Its antitumor and antimitotic properties make it a potential candidate for the treatment of various types of cancer.
Used in Drug Delivery Systems:
10-Deacetyl-13-oxobaccatin III is used as a component in drug delivery systems to improve the bioavailability and therapeutic outcomes of cancer treatments. Its stability and effectiveness can be leveraged to develop novel drug formulations and delivery methods, enhancing the overall efficacy of cancer therapies.
Used in Pharmaceutical Industry:
10-Deacetyl-13-oxobaccatin III is used as a key intermediate in the synthesis of various anticancer drugs, contributing to the development of new and improved pharmaceuticals for cancer treatment.
Used in Research and Development:
10-Deacetyl-13-oxobaccatin III is used as a research tool for studying the mechanisms of action and potential applications of natural compounds with antitumor and antimitotic properties. Its unique structure and activity make it a valuable asset in the ongoing quest to discover new and effective cancer treatments.

Upstream product

• 32981-86-5 10-deacetylbaccatin III 

Downstream Products

• 155588-21-9 7-triethylsilyl-13-dehydro-10-deacetylbaccatin III 
• 285118-36-7 C₄₁H₆₄O₉Si₂ 
• 285118-35-6 C₄₁H₆₂O₉Si₂ 
• 358621-68-8 5⁽²⁰⁾-deoxy-5⁽²⁰⁾-sulfanyl-7,10-di(triethylsilyl)-13-[[(4S,5R)-2-(4-methoxyphenyl)-3-(tert-butyloxycarbonyl)-4-phenyl-1,3-oxazolidin-5-yl]carbonyl]-10-deacetylbaccatin III 
• 358621-67-7 7,10-di(triethylsilyl)-5⁽²⁰⁾-deoxy-5⁽²⁰⁾-sulfanyl-10-deacetylbaccatin III 
• 358621-66-6 7,10-di(triethylsilyl)-5⁽²⁰⁾-deoxy-5⁽²⁰⁾-sulfanyl-13-oxo-10-deacetylbaccatin III 
• 518021-34-6 C₃₇H₄₂O₁₅ 
• 518021-33-5 C₃₆H₄₄O₁₄ 
• 518021-32-4 C₃₆H₄₄O₁₃ 
• 32981-91-2 7-O-acetyl-13-oxobaccatin III 
• 32981-89-8 13-oxobaccatin III 
• 184645-50-9 7,10-di(triethylsilyl)-13-oxo-10-deacetylbaccatin III 

Relevant articles and documents

THE CHEMISTRY AND OCCURRENCE OF TAXANE DERIVATIVES. XIII. THE OXIDATION OF 10-DEACETYLBACCATIN III

The three secondary hydroxyls of 10-deacetylbaccatin III, 1, can be selectively oxidized.However, only the 13-dehydro derivative is stable under the reaction conditions, whereas the 10- and the 7-dehydro derivatives undergo epimerization at C-7 and oxetan