92851-65-5

Basic information

• Product Name: Benzeneacetic acid, a-[[(4-methylphenyl)sulfonyl]amino]-
• CAS NO: 92851-65-5
• Molecular Formula: C15H15NO4S
• Molecular Weight: 305.354
• Mol File: 92851-65-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzeneacetic acid, a-[[(4-methylphenyl)sulfonyl]amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, a-[[(4-methylphenyl)sulfonyl]amino]-(92851-65-5)
• EPA Substance Registry System: Benzeneacetic acid, a-[[(4-methylphenyl)sulfonyl]amino]-(92851-65-5)

Safety Data

• Hazardous Substances Data: 92851-65-5(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 2835-06-5 phenylglycin 
• 124-38-9 carbon dioxide 
• 70-55-3 toluene-4-sulfonamide 
• 114551-38-1 ((trimethylsilyl)oxy)(phenyl(CH))tributylstannane 
• 1129-26-6 4-methoxybenzene sulfonamide 
• 1423047-90-8 N-tosyl-α-(tributylstannyl)benzylamine 
• 100-52-7 benzaldehyde 
• 6000-59-5 glyoxalic acid monohydrate 
• 98-80-6 phenylboronic acid 

Downstream Products

• 159831-04-6 DL-benzyl 2--2-phenylacetate 
• 103-82-2 phenylacetic acid 
• 1562347-04-9 4-methyl-N-[(3-methyl-4-oxo-4H-[1,3,4]thiadiazolo[2,3-c]triazin-7-ylphenyl)methyl]benzenesulfonamide 
• 157699-62-2 C₂HNIrO(O)(C₅(CH₃)5)(SO₂C₆H₄CH₃)(C₆H₅) 
• 74641-60-4 2-methylamino-2-phenylacetic acid 

Relevant articles and documents

Sulfonamides as Amine Component in the Petasis-Borono Mannich Reaction: A Concise Synthesis of α-Aryl- and α-Alkenylglycine Derivatives

A catalyst-free three-component synthesis of α-aryl- and α-alkenylglycine derivatives starting from glyoxylic acid, sulfonamides, and aryl- or alkenylboronic acids is described. This operationally simple method tolerates a broad range of functional groups and enables the generation of a wide array of α-amino acids. Sulfonamides were utilized as amine component in the classic Petasis reaction for the first time.

Design, synthesis and collagenase inhibitory activity of some novel phenylglycine derivatives as metalloproteinase inhibitors

Metalloproteases are a class of proteases having metal ion(s) at their catalytic sites. Bacterial collagenases are involved in human gas gangrene, periodontal diseases, food etc. The Clostridium collagenase occurs in two isoforms COL_G and Col_H. The present work is based on the protein structure-based approach for the development of collagenase inhibitors. The sequence analysis and structural alignment of both isoforms showed significant similarity in active site except aspartate switch present in Col_H. The homology model was developed and validated for Col_H peptidase domain with open aspartate switch followed by the docking of designed ligands. Compound 8b showed better interaction due to the presence of the nitro group. The N-benzyl-arylsulfonyl-phenylglycine derivatives were synthesized and characterized by FT-IR, 1H NMR, 13C NMR and mass spectral analysis. The compounds were evaluated for C. histolyticum collagenase inhibitory activity using gelatin-ninhydrin based assay. Compounds 5b, 3b, 11b, 6b and 8b with IC50 of 24.34 μM, 29.61 μM, 28.39 μM, 31.4 and 32.11 μM respectively were found to be more active. Further, The Ki of most active compound 5b was found to be 22.02 μM showing the competitive mode of inhibition of the enzyme. The activity of the derivatives showed correlation with the docking results.

Aminoacids in the synthesis of heterocyclic systems: The synthesis of triazinoquinazolinones, triazepinoquinazolinones and triazocinoquinazolinones of potential biological interest

A number of novel triazinoquinazolinones (5b,c and 8), triazepinoquinazolinones(5a, 6b, 7 and 9) and triazocinoquinazolinones (6a and 10) were obtained via nucleophilic interaction of 3-aminoquinazolinone derivatives 3 with different reagents.