92653-04-8

Basic information

• Product Name: ethyl 2-(acetamido(phenyl)-methyl)-3-oxobutanoate
• Synonyms: ethyl 2-(acetamido(phenyl)-methyl)-3-oxobutanoate
• CAS NO: 92653-04-8
• Molecular Weight: 277.32
• Mol File: 92653-04-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: ethyl 2-(acetamido(phenyl)-methyl)-3-oxobutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(acetamido(phenyl)-methyl)-3-oxobutanoate(92653-04-8)
• EPA Substance Registry System: ethyl 2-(acetamido(phenyl)-methyl)-3-oxobutanoate(92653-04-8)

Safety Data

• Hazardous Substances Data: 92653-04-8(Hazardous Substances Data)

Upstream product

• 6907-68-2 N-[phenyl(acetylamino)methyl]acetamide 
• 108-24-7 acetic anhydride 
• 141-97-9 ethyl acetoacetate 
• 100-52-7 benzaldehyde 
• 75-05-8 acetonitrile 
• 75-36-5 acetyl chloride 
• 119020-88-1 N-(1-benzotriazol-1-yl-1-phenylmethyl)acetamide 

Downstream Products

• 40638-98-0 (R/S)-3-(acetylamino)-3-phenylpropanoic acid 
• 471259-71-9 (RS)-3-amino-3-phenyl-propionic acid hydrochloride 
• 480443-48-9 3-pent-4-enoylamino-3-phenyl-propionic acid 

Relevant articles and documents

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Silica-supported perchloric acid (HClO4-SiO2): An efficient catalyst for the preparation of β-amido carbonyl compounds using multicomponent reactions

A new, one-pot, efficient, three-component condensation of benzaldehyde derivatives, enolizable ketones, acetyl chloride, and acetonitrile or benzonitrile in the presence of silica-supported perchloric acid as an effective catalyst for the synthesis of β-

One-pot multicomponent synthesis of β-acetamidoketones catalysed by pTSA1

A catalytic amount of pTSA has been found to be effective to carry out a one-pot three-component coupling of aromatic aldehydes, enolizable ketones or ketoesters, and acetonitrile in the presence of acetyl chloride to afford β-acetamidoketones in high yields. Short reaction times and inexpensive catalyst are main advantages of this protocol.